An Antidote for Being Too High? Mary’s Rescue Tonic

Nicole Smith

Have you ever been too high, taken too many edibles, taken one too many hits off a joint? well Nicole Smith from Mary’s Medicinals thinks she can help you with that problem. Mary’s Rescue is a small drink that can help bring you down when you feel you over-medicated.

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Key Takeaways:
[1:15] – Nicole’s background
[2:12] – Nicole discusses products offered by Mary’s Medicinals
[3:18] – Nicole compares and contrasts transdermal, smoking and edibles
[4:22] – Nicole discusses the cannabinoid profile of the patches
[5:23] – What is CBD
[6:35] – Nicole talks about their extraction process
[8:42] – Best place to use the patch
[9:22] – Nicole describes how the gel pen works
[10:24] – Nicole discusses Mary’s Rescue Tonic
[13:39] – Nicole discusses packaging of their products
[15:09] – What’s ahead for Mary’s Medicinals
[16:16] – Contact details for Mary’s Medicinals

Click Here to Read Full Transcript

Matthew: Hi, I’m Matthew Kind. Every Monday and Wednesday look for a fresh new episode where I’ll take you behind the scenes and interview the insiders that are shaping the rapidly evolving cannabis industry. Learn more at That’s Are you looking for a fulfilling and lucrative career in the cannabis industry? Visit That’s Now here’s your program.

We’ve all had the experience of being too high, taking one too many tokes, rips or edibles and wishing we could turn back the clock and not take that last one. Nicole Smith, CEO of Mary’s Medicinals, thinks she has solved that problem with her product called Mary’s Rescue Tonic. Welcome to CannaInsider Nicole.

Nicole: Thank you very much for having me.

Matthew: To give listeners a sense of geography, can you tell us where you are in the world today?

Nicole: Yeah I am in Denver, Colorado at our new facility here.

Matthew: Before we jump into all the interesting products Mary’s Medincinals offers, can you tell us a little bit about yourself and how you got started in the cannabis industry?

Nicole: Yes I was running a business development and marketing company for about 12 years, and literally Mary’s came about as a challenge. Over a couple of drinks New Year’s Eve somebody was talking about the cannabis industry and how more and more people were coming into the industry and the price of cannabis was being driven down by all of the new growers. And so they asked me about what I would do in the industry if I could. I said well I’ve used or develop a product that would make the best use of a limited ingredient like transdermal delivery. And they said ah, bullshit you can’t do that. And I said you know what I think I can. So basically the company was really started on a challenge.

Matthew: Like a dare, what a great way to start a business.

Nicole: Well and it’s been… it’s been a wild ride since.

Matthew: I mentioned Mary’s rescue tonic, but can you tell us a little bit about the other products that you offer?

Nicole: Yeah so of course our flagship product is our transdermal patch, but we evolved into doing another type of transdermal delivery which is a gel, it’s kind of like a cream, and I consider it similar to something like an androgel or a steroid cream, same type of delivery. We do capsules as well and a tie in to topical compound.

Matthew: Okay. Now for people, transdermal patch, I mean is this the type of thing that people can visualize like a Nicorette type of patch? Is that what it’s like?

Nicole: Yeah absolutely, same kind of style for a hormone patch. They are 2X2 inch squares, flesh colored, and they are applied to a venous area of the body. We suggest the top of the foot or inner wrist. There are effective in about 10 to 15 minutes and have a lasting time of up to 12 hours.

Matthew: So let’s kind of compare the come on of smoking versus edibles versus transdermals. How would you compare and contrast those three things?

Nicole: Yeah. I think first and foremost all of our products were designed truly with the medical patient in mind. Eighty percent of them are non-psychoactive, and so we’re not looking at how high did I get. We’re looking at how much pain relief or how much symptom relief did I receive from the product over a period of time. So they’re faster acting and so they’re probably, you know, acting in the same time as actually smoking or vaping sort of from an ethicacy standpoint. From a lasting time it’s probably four times longer than anything on the market unless you just truly over consumed. But you’re getting that slow sustained relief over a period of time. So that helps our patients just get greater pain relief without having to consume again multiple times.

Matthew: Okay so you’re focused on the pain relief aspect. So can you give us some examples of kind of the cannabinoid profile of the patches or pens that, you know, what the THC concentration is relative to maybe CBD or CBN?

Nicole: Yeah, absolutely. So we accurately dose all of our products. So if we deliver a 10mg patch, it’s going to have 10mg of the cannabinoid specified. So we’ll have 10mg of CBD or THC. Right now we do a variety of types. So we do indicas and sativa, 20mg patches. We have our CBD. We do a one to one product which is CBD and THC, 5mg of each. We make a CBN product which is unique to Mary’s, and then we also make a THC-A product which is the non-decarboxylated form of THC. It has a greater bio-availability and it’s a great anti-inflammatory without any of the headiness or associated high.

Matthew: Wow. Now a lot of listeners are familiar with CBD and obviously THC but not CBN. Can you just touch on that for a minute, what that is and how we should think about it?

Nicole: Yeah. So CBN is the breakdown of THC. So one of the common ways I describe it is that if you’ve had marijuana that sat too long, you know, or was in the back of the cabinet for a while and you smoked it, you’d get sleepy. It’s because THC breaks down to CBN. So what we do is in our laboratory we force THC to convert to CBN. And what we’ve found is that it’s great for insomnia and for people needing a sleep aid, but it also works as an antispasmodic for different types of muscle spasms.

Matthew: Okay. Now there’s a lot of different opinions out there in terms of extracting CBD from hemp versus you know cannabis flower. And maybe hemp has gotten whipped a little bit too much because it’s possible to get hemp from unreliable sources or dirty sources, but the same is true for cannabis and these are all sister plants to begin with. They’re under the same umbrella of cannabis. How do you prefer to extract CBD, hemp or cannabis flower or sugar leaves?

Nicole: Yeah Mary’s is actually in a very unique situation right now. We have a partnership with Elite Botanicals that’s cultivating cannabis sativa plants that are under the .03 percent dry weight which by federal law deems them to be hemp, and they’re being grown here in Colorado, but we’re able to use beautiful, crystalline flowers to make all of our CBD extracts.

Matthew: Wow that’s pretty clever. Okay. And extraction, do you use CO2, ethanol, butane, where do you stand on that?

Nicole: Yeah we use ethanol right now. We’ve used a variety of solvents and hydrocarbons over the past two years. But we’ve just recently went to using an organic ethanol.

Matthew: Now there’s a lot of people out there who come into the cannabis industry and create like a me too product and they wonder why they have difficulty selling. Was part of your thought process, you know, hey I’m going to create something so different here that it’s really going to stand out or what were you thinking when you were developing this?

Nicole: No, we were really just filling a void in the industry and as we started looking at the industry and talking about developing the transdermal patch, we realized that there were very few products on the market that were accurately dosed or that were pharmaceutical in nature. Maybe a couple of capsules entering the marketplace, but still very few. And I just always found it to be such a you know juxtaposition of people fighting for cannabis as medicine, but yet only having a deliver method of a gummy bear or a brownie. And so that was really what propelled us to develop the types of products that we have. And so everything that we do create now, you know, adhere to our basic principles for accurate dosing and clean delivery.

Matthew: And is there any place on the body that’s preferable to put a transdermal patch versus another maybe that you’ve seen anecdotally, I mean that you could share?

Nicole: Yeah so the issue with cannabis patches is that cannabinoids like to bind to fat. That’s why when we consume cannabis or smoke marijuana it stays in our system for a very long time. It’s because it holds on to fatty cells in the liver. So we want to avoid putting the patch anywhere where we have a high fat content and we’re looking for very vascular areas like inner wrist or top of foot, back of knee, that kind of place.

Matthew: Okay. Now when you say you offer a gen pen, can you describe that a little bit more? I don’t know if everybody is familiar with how a gel pen would work.

Nicole: Yeah so we call it a pen only because it’s an accurately dosed dispenser which again is true to who we are. And so the dispenser measures a 2mg dose of cream per each pump, and that’s why we call it a pen. But the cream then can be applied anywhere, again vascular area or even directly to the temples for migraines.

Matthew: Interesting. Okay. Now let’s talk a little bit about the rescue tonic, Mary’s rescue tonic which helps alleviate these symptoms to being too high. I met you at the Denver Cannabis Cup, and there was people I believe sitting nearby who had just drank some and kind of trying to chill out so they can, you know, the symptoms of being too high can kind of abate. Can you tell us what’s the science or what’s the logic behind the ingredients in Mary’s Rescue Tonic that actually alleviates that feeling of being too high?

Nicole: Yeah so it’s doing a couple of things. First and foremost it’s combating the symptoms of over consumption which are generally are panic or paranoia, loss of mental focus. And so we’re using all natural ingredients to help combat those symptoms, but we’re also included ingredients that are helping the body flush THC through the liver more rapidly.

Matthew: Interesting okay. Now is there a primary ingredient that helps do that?

Nicole: So we have a proprietary blend of a few ingredients. But we do use acetylcholine or a version of acetylcholine which was studied extensively when Dr. Robert Melamede was doing his studies with epileptic children he would use acetylcholine to block the uptake of THC so the kids were only receiving the effects of the CBD in his trials. And it was part of that reading and research that led us down the path to developing this product.

Matthew: And so I mean people can have a varied range of feeling too high. They can be a fast metabolizer or a slow metabolizer of THC so there’s a lot of variable here, but anecdotally do you get… what’s the feedback you get as far as how long it takes before symptoms abate?

Nicole: We’re seeing within about 30 minutes. Folks are reporting that they feel a significant decrease in their symptoms.

Matthew: We should really almost give these to tourists who come to visit Colorado proactively.

Nicole: We are very pleased, actually we have a three month exclusive agreement with Native Roots to distribute the Mary’s Rescue product. And in fact that was one of the things that they had discussed is just making it available on the rec side or even giving it away with recreational sales as a responsibility measure.

Matthew: Yeah that really, that’s a good idea. Although then you’re caught in this kind of Catch 22 if you’re someone that’s kind of coming to have fun like hey I can always just bring myself down if I get too high so I’m really going to, you know, go crazy here.

Nicole: You’re going to overdo it, yeah that’s an interesting concept.

Matthew: But if you’re starting out with that logic, you know, perhaps...

Nicole: It might be best. You know I think that anybody who’s ever gotten there generally tries to avoid going back there. And it’s nice to know that there’s an option, and that was the one thing that I found in developing the product is that even when I talk to people I know that are heavy consumers, recreational consumers, they still understood and appreciated the product because if not for themselves on that application, then for somebody they know or a friend or a girlfriend or someone.

Matthew: Yes someone visiting that’s just not that familiar or comfortable. Now your packaging really stands out. I’ve noticed it at dispensaries, and you have a really good way with design. How do you think about packing? Is it just something that flows or do you have a strategy? What can you tell us there?

Nicole: Part of that came out of my owning a marketing firm for 12 years prior to doing this. So brand and packaging and messaging has always been critical to me and something that we just adhered to from the get go. And we also wanted to make sure that our packages stood out. Again 80 percent of what we’re making is nonpsychoactive. We have no desire to appeal to children. And so we wanted our packaging to be very simple, very clean, easy to read and actually very visible in the store by being just simple and in high contrast to all of the greens and tie dyes and intense products going on.

Matthew: So is it possible to do the rescue tonic in a transdermal patch or is that something that’s really not of interest?

Nicole: No, and primarily because the patch isn’t.. well it’s fast acting. It’s fasting in slow release, and so you wouldn’t be getting the same, you wouldn’t serve the same objective. We want to bring somebody down quickly and keep them, you know what I mean, keep them down and not necessarily continue to deliver that same medication over a long period of time. We want them to have immediate relief as possible.

Matthew: Well you certainly have products that stand out. What’s next for you looking at the year ahead?

Nicole: Some areas of continuing to expand into other states. Very pleased to announce that we just signed our agreement for Arizona, and I’m travelling there today which make Mary’s a five state company now. We’re looking to be eight, eight by the end of the year. And then we will be launching this week online sales of our hemp based CBD product and are actually looking towards a line of CBD, the transdermal gel for pets.

Matthew: Okay. And I mean it’s kind of difficult because state is every state is a fiefdom. You’re dealing with a whole batch of regulations here in Colorado and then when you go to Arizona do you create like a licensing agreement with a partner?

Nicole: Yeah we do, that’s exactly right. We do a licensing agreement and we’re licensed in our intellectual property and our brand, and then instruct them on how to manufacture products in each of those states.

Matthew: Very good. Great. Well Nicole where can listeners learn more about Mary’s Medincinals?

Nicole: Always at and on Facebook, Twitter and Instagram @marysmedicinals.

Matthew: Nicole thank you so much for being on CannaInsider today. We really appreciate it.

Nicole: Well thank you so much for having me. It was really interesting.

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