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Ep 279 – Lab Grown Cannabinoids Looking to Disrupt Growers

kevin chen hyasynth bio

As cannabis cultivators pour billions of dollars into developing cutting-edge, efficient grows, we need to ask: is there a hidden disruptor that could steal their business in the years ahead?

Here to help us answer this is Kevin Chen of Hyasynth Bio, one of just a few companies experimenting with non-plant-derived cannabinoids.

Learn more at https://hyasynthbio.com 

Key Takeaways:

  • Kevin’s background in cannabis and how he came to start Hyasynth Bio
  • An inside look at Hyasynth Bio and its work with non-plant-derived cannabinoids
  • A deep dive into biosynthesis and how Hyasynth Bio uses this process to grow cannabis compounds inside yeast cells
  • How Hyasynth Bio has successfully overcome challenges with biosynthesis
  • The history of biosynthesis and cannabis and where Kevin sees this relationship evolving in the years to come 
  • The different types of end products we’ll start to see for sale in dispensaries that use biosynthesis
  • How biosynthesis will affect cannabis prices
  • Hyasynth Bio’s intellectual property strategy and how Kevin manages the company’s patents
  • The traditional cannabis companies that are investing in biosynthesis
  • Where Kevin sees cannabinoid biosynthesis heading in the next 3-5 years
Click Here to Read Full Transcript

Matthew: Hi, I'm Matthew Kind. Every Monday, look for a fresh new episode where I'll take you behind the scenes and interview the insiders that are shaping the rapidly evolving cannabis industry. Learn more at cannainsider.com. That's cannainsider.com. Now, here's your program.

As cannabis cultivators pour billions of dollars into creating cutting-edge efficient grows, we need to ask, is there a hidden disruptor lurking that may steal their business in the years ahead? Here to help me answer that question is Kevin Chen, CEO of Hyasynth Bio. Kevin, welcome back to "CannaInsider."

Kevin: Great to be back.

Matthew: Great. Give us a sense of geography. Where are you in the world today?

Kevin: I am in Montreal where we have our labs and offices. And right now I'm actually in one of our, like, back storage rooms because our conference room is fully occupied and we're moving a bunch of stuff around with some new instruments. And so the storage room is the quietest and most private space right now here. But yes, surrounded by boxes and desks and instruments, and yeah.

Matthew: I appreciate you going deep cover for the interview, resourceful. That's a good trait in an entrepreneur.

Kevin: Of course. Yeah. It's part of...I mean it's part of communication I guess to give context to where we're at.

Matthew: Yeah. So you were on the show a year or two back, but for new listeners, can you give us a summary of what Hyasynth Bio is?

Kevin: Definitely. So you could describe us almost maybe as one of these hidden disruptors that are coming up to the industry and gonna change a bit of how this industry works. But our basic goal here is to create strains of yeast that you can use in industrial fermentation the same way that you may be brew beer or produce insulin and then use the yeast to produce THC and CBD without having to grow plants at all. And so as opposed to like, you know, a plant growing cycle or where you have to have all this light and energy and it takes three months to grow, a yeast will grow in about a week, and then you can do an extraction and purification from that, which is also relatively straight forward. And then you end up with like your purified, you know, ingredient that you can use and all kinds of different applications. So we really want to take advantage of that, like industrial fermentation system and process that so many industries rely on today, and bring that to the cannabis world.

Matthew: Okay. And as I mentioned, you were on the show a couple of years back, but could you share a bit about your background and journey and how you got into the cannabis space?

Kevin: Yeah, definitely. So my background is primarily in biochemistry. So I'm coming from a science background and then I got interested in, I guess, the cannabis industry as a whole back in 2014 when we were sitting around as co-founders and talking about some ideas of, you know, startups that we could do. And I guess we were a bunch of people who knew very well how to engineer a yeast to do all kinds of different things, and some of our previous work was with the yeast or algae to produce different kinds of like anticancer drugs or to produce maybe like precursors for plastics, things like that. So we kind of had our laundry list of ideas of things that we could make using a yeast. And cannabinoids was one of those, opioids was another one actually. Those two industries are gonna be headed in opposite directions, I guess.

And so we started with cannabinoids, investigated a bit further. I got a chance to meet a lot of the researchers and patients and companies that were, you know, working in the cannabis space and just getting started. And that really gave us, you know, a good amount of inspiration and motivation to kind of see, you know, how important, you know, these compounds are and how important it will be to have a really good supply chain for these things in the future. And that's how we got into it.

Matthew: Okay. Yeah. Like three months back, I think it was, I was up in Montreal and you were kind enough to give me a tour of your facilities. Can you talk a little bit about your lab and just walk us through what you showed me there?

Kevin: Yeah, definitely. So I guess we're divided up into a few different sections of, you know, genetic engineering and fermentation and analytical chemistry. So what you walked by would have been like, you know, kind of walls of freezers and incubators and shakers and some robotics stuff and a lot of machines that do all kinds of different things. But our typical workflow is to basically try and generate and screen as many different kinds of yeast strains or enzymes that are involved in cannabis biosynthesis as we can. So, you know, we're always working in the scales of, you know, thousands of samples per week. And whether it's like, you know, a new strain of yeast that we're trying or a new version of like the cannabis, you know, THC biosynthesis enzymes that we're trying, there's all kinds of different things that we'll do. And that's maybe like, you know, the bulk of what our work has been like for the past while.

The next phase after we've got these strains of yeast, of course, is to do like production. And that's what we're producing in a much larger volume of the vessel and actually purifying material out and then having that sent...you know, either verified internally or maybe sent externally for validation. And that's like the kind of like production and quality workflow that is becoming more important now as our strains get closer and closer to completion.

Matthew: Okay. And what's the relationship, or maybe you can name the university and what's the relationship with the university? Because you're kind of like on the edge of campus or even on campus. They're kind of fostering, you know, innovation with graduates. So maybe you could talk a little bit about what's happening there.

Kevin: Yeah, a little bit. I can tell you, we are on the campus of the university. The university that we are inside of, I guess, we don't have a specific relationship aside from a lease, I guess. And you know, it's a good location and the lab space is great. And it's the University of Quebec in Montreal and we're really happy to be here and have this location just because it's nice space and nice location. A lot of our teammates are coming from Concordia or McGill University and with each of these universities, maybe we've had a bit more of like, you know, either a hiring relationship or other kinds of like startup, you know, initiatives that exist there. And so I can point to them better as far as like, you know, universities that are pushing more startups and getting things out, which is interesting. And here we're, yeah, mainly just renting space, I guess.

Matthew: Okay. And biosynthesis is a term some people get stuck on. I mean, that's the whole thrust of your business. But for people that get stuck on that term biosynthesis, is there ever a way you can help them get unstuck in a simple way? You're so deep in the weeds, it's probably like, it's so clear to you.

Kevin: Yeah. No, I just did a big, long meeting with another investment banker and he was tearing apart my slide and saying like, "All this stuff, you just don't need," you know, he doesn't get it and it doesn't matter. Just curious about, you know, the profit and the margins and stuff like that. I was like, "Okay, I guess so." But...

Matthew: I care about it, I disagree.

Kevin: Yeah. And I mean, being from scientists also, his comment is like, you know, "It's clear you like to teach people about what you're doing and that it is science," and it is fun to teach. So I do still enjoy that and I won't...I'll take away...I'll dial it back a bit, but I guess I'll give you the...I mean, the quick spiel about biosynthesis is that as far as like coming back to the basics of like how biology works is that, you know, your cells themselves are machines. And maybe I'll use insulin as an example of where, you know, there are cells in your pancreas that produce insulin. And that you need that to help regulate, you know, your glucose and this is how if that doesn't work properly, then you end up with, you know, conditions like diabetes.

And so, you know, back in the 1970s and '80s, people figured out how to produce insulin using a bacteria and then that became something that can be dosed as an actual drug. And that's, you know, most of what we know of as like, you know, the insulin today being used for treating diabetes. So, you know, it's the same kind of analogy there where, you know, there is, you know, cells in cannabis plants that are responsible for producing THC and producing CBD. And inside those cells, there's a whole lot of chemistry happening to do that.

And our goal is to replicate that kind of chemistry, but inside of yeast cells, which grow a lot faster and are lot cheaper to grow and create that same sort of equivalent where, you know, we don't need to grow cannabis anymore, we can just grow yeast and have a much more stable and reliable supply chain for this. So, you know, that's kind of how it works. And then getting into the deeper weeds is like, you know, it is genetic engineering and we are changing a lot of different parts of a yeast genome, but this is a yeast that started out maybe as like a typical brewer's or a baker's yeast kind of thing. Did I get too far into the weeds or is that a good overview?

Matthew: No, no. No, I think that's good because it's more context.

Kevin: Yeah, definitely. And it is like such a complicated and interesting field because, you know, some parts of it really touch on the yeast that you do use for baking and brewing and ways to like engineer and modify that or to breed new types of yeast that give different flavors for like, you know, I guess if you think about the flavors of beer where you have like, you know, your range of sour beers and also like other kinds of beer that part of that flavor is driven by the yeast and which yeast it is and the genetics of that yeast. And then, you know, maybe that's a kind of introduction to using fermentation to handle, to produce flavors and to boost fragrances that are unique. And then in our case, you know, getting a bit more hands on where, you know, we're trying to be growing something very specific in a really specific, you know, way as opposed to dealing with, you know, breeding and wild fermentation kind of stuff. But a lot of the concepts kind of start to align when you think about they know the science and the chemistry of what's actually going on inside these yeast cells to produce different like flavors and fragrances or, in our case, cannabinoids.

Matthew: Yeah. So growing cannabinoids and yeast in a lab environment, and obviously, you know, at a 10,000-foot level when I went into your lab, I'm like, okay, you guys are creating cannabinoids in a lab and cultivators are more like farmers and there's just, you know, juxtaposing these two things. It's just very clear like, wow, and something's gonna happen to here. It's hard to know what, maybe these two fields will merge. Maybe one will take over, but you have a lot more ability to change things in a profound exponential way than a traditional cultivator. But, I mean, why is biosynthesis not bigger than it is right now? What's kept it from scaling up to this point?

Kevin: Yeah, it's a big challenge on, I mean, the scientific front, maybe specifically, to just engineer a yeast that does these kinds of things. And if I think about a good story to tell here, like I think biosynthesis kind of technologies and sort of genetic engineering has had a lot of different kinds of challenges over the past few years. I mean, if you think about the insulin type of thing I just described, how that's like the major way to produce insulin now, that was a great success story and that was like the 1970s and '80s that got first developed. And then over the past like, you know, 15 to 20 years, there was a lot of attention going towards using biosynthesis in the biofuels world. And that was a really, you know, interesting story because it was like huge amounts of investment that went into these, you know, people that were trying to engineer yeast or algae or whatever to produce biofuels. And then it just kind of tanked in the end and a lot of money that, you know, was invested into this kind of R&D went to waste because in the end you couldn't, you know, grow sugar, which is maybe the main feedstock for a yeast cheaper than you could buy, like, gasoline, right? And the economics were never quite perfect enough that that needed to move forward.

There's still some like stuff coming out now. I think that's like, you know, the newer version of the biofuels stuff that is kind of on its way to market. But it's really hard to just kind of, you know, walk into a room and say that you're an engineer yeast to do something. Or I guess, sorry, it's easier to walk into...It's easy to walk into a room and say that but then when you actually get into it, then, you know, you're still dealing with an organism that has its own priorities as far as, you know, wanting to grow faster or slower depending on how you feed it and everything like that. And so the science starts to get really, really challenging.

And this is why, you know, in our case it is about, you know, screening thousands of different strains and samples and ways to do this stuff and as opposed to like, you know, hundreds. And so, you know, maybe there's a big, you know, scientific challenge in the biosynthesis world that has always made it hard to develop these kinds of technologies and kind of like to say that. But I think we're getting to close to a point now where it is gonna become more of like a normal thing to start to see biosynthesis take over different industries, not just cannabinoids. And maybe we're recovering a bit from this like, you know, huge failure of the biofuels kind of thing.

Matthew: Okay. So you think we are approaching some sort of transition where finally there's gonna be that leap that's needed and is that gonna come from looking at so many different strains and maybe manipulating them on a genetic level?

Kevin: That's gonna be definitely part of the story. And it's like, you know, seeing how the kinds of challenges that we've run into that like, you know, a lot of it's kind of unexpected, but then, you know, you can find ways to deal with these different challenges that you can get. And then whether that's something that has to be changed on your process or with the, you know, genetic engineering or whatever else, either way, like, you know, I feel like, you know, today maybe we...over the course of enough years of experience, like we've got a good handle of how to solve a lot of these like yeast engineering problems and it's, you know, maybe closer to being a finite amount of time and money that has to be invested to complete a biosynthesis pathway. And in our case right now, you know, we've already done it, we've made cannabinoids using our yeast. Now, there's some more like process improvements and strain improvements that we need to make. And that's, you know, even more of a clear, you know, sign that this is gonna happen. There's not gonna be any like really big issues. This isn't like discovery science anymore. And I think we'll start to see that kind of across different industries that are like anything like, you know, chemical or bio products. Yeah.

Matthew: Okay. What end products do you see being first to market in a dispensary that use biosynthesis?

Kevin: That's a good question. I don't know. I mean, I would say not...I mean obviously not like cannabis plants because you're still...it's the cannabis plant that you're smoking, right? So that's not gonna change really. But almost, you know, anything else like, you know, the cannabis oils or maybe the other kinds of derivative products like edibles and stuff like that, we'll start to see...I mean in our case, you know, it is also kind of like, you know, let's see, you know, once we are ready to start like marketing products and putting things on the shelves, we'll have a decision point where we'll have to decide exactly what it's gonna be. And I don't know if I can say specifically what it will be today. Partly because we're still like exploring to some extent and seeing who wants to develop the next best thing.

And I mean, one of the big questions I think overall for the entire cannabis industry is also like, you know, what is the future of, you know, these products, like is cannabis oils, like, you know, the default way to use cannabis or is it gonna be kind of as pills or is it gonna be like a food, like a beverage kind of thing? And maybe that's more, like, you know, what'll help drive our decision-making process for who we're gonna work with and how we're actually going to like, you know, get our stuff onto dispensary shelves somewhere.

Matthew: When I think of Anheuser Busch and their huge manufacturing facilities in the U.S. or up there in Montreal and saw the big Molson facilities, what's it gonna take for biosynthesis to be at that level, like producing cannabinoids there, like what kind of leaps are gonna have to happen? It's just finding the right strains?

Kevin: Yeah. It's partly just finding the right strains. And I mean there's challenges all along the way and I mean it's just a matter of making sure that your research teams are experienced and that you've, you know, got the right approach to managing the capital that is going to go into this kind of, you know, larger-scale facilities. In a lot of cases, there are, you know, manufacturers that you can hire just to do this kind of manufacturing. That's one of the big advantages here is that, you know, unlike a lot of cannabis growers where you sort of had to start, you know, build a greenhouse from scratch almost especially in....or especially if growing indoors, you kind of have to build a specialized facility for this kind of stuff. In the industrial fermentation world, there's already industrial fermenters that exist and then you can either buy those or hire them to do work for you.

So, and then those companies will have experience of taking strains from like small scale to like, you know, immense scales like the ones that you see in these, you know, beer fermentation breweries. So there is like a, you know, rational way to actually go about doing the scale-up. It's not risk-free, but it's at least, you know, you can manage that risk. And this comes back to maybe a bit of like, you know, our experienced that, you know, as we get into it, that will help drive our strategy there is, you know, again, having staff who have spent a lot of time around the biofuel stuff and seeing a lot of companies go up and down.

Matthew: Okay. Kevin, has there been interest from brewers or it's been more cultivators or investors? I mean, who's kind of interested here? I would think this is kind of the brewer's bread and butter because they're used to yeast at a huge, you know, manufacturing level. Has there been interest there from brewers?

Kevin: Yeah, there definitely has to some extent at least, but there's also some like, you know, divergent, you know, ways to do fermentation that like, in one case, we're trying to produce like, you know, beer. In our case, we're trying to produce like a fine, you know, chemical in the end. So the types of fermenters that you would use are a bit different and it's not like a perfect crossover. But the skillset and like the experience is still the same where like, you know, you are dealing with huge fermentations and there's capital risk to manage there. And so people who understand that are like people that I like to talk to you too. But we have gotten a lot of interest from, you know, maybe all kinds of the same areas of people who are just like looking at the cannabis industry. They'll often come across our type of technology and kind of approaches to see how this might, you know, affect their investments or if it's a cannabis cultivator, then they, you know, wanna know how this might affect their own company as a whole. And so it's a bit of like all of the above, I guess. And we're always happy to have, you know, these conversations and to see, you know, who's interested and see if this relationship to build now or something in the future.

Matthew: Yeah. I try to think about how this will impact cannabis pricing, you know, for a kilo or a pound of cannabis. And I'm thinking it's gonna be less of an impact on flower, dried flower, but extracted oil, that's where the margin hit might come from because this is effectively what you're creating is probably an input or ingredient to some other finished product. So is that what you're kind of thinking too?

Kevin: To some extent, yes. I mean overall, it is a more efficient process. But there's tons of also new stuff that we'll get into that'll be more about building specialized formulations or starting to target some of these more rare cannabinoids because we can engineer, you know, strains to produce those too. So I think there's a few different business models that will kind of like play out and there'll be...you know, in one case, you know, we can focus a lot on these, like, newer formulations and increase the diversity of the products available on the market and have like some really unique stuff come out. And then there's also like, you know, maybe focusing on that commodity style, like ingredient supply where it is about, you know, having cost metrics that start to make sense for like the, you know, really large scales and for like a mass-market product and where those costs of, you know, cannabis oils or there kinds of products that might start to come down, which to some extent, I would argue they almost need to anyways.

If you think about, you know, the way that a lot of other food and beverage industries kind of work and how those margins are like and what the cost of ingredients is there, I think, you know, from some of the conversations that I've had, like the cost of growing cannabis is like, you know, way beyond anything that people would consider for, you know, being a food and beverage ingredient. And that prevents a lot of people from even entering this market at all. And so I think, you know, in order for the cannabis industry to...yeah, coming back to, like you said, maybe we're disrupting the cannabis industry. But maybe, in reality, this is about, you know, the natural scale and the growth of the cannabis industry that becomes important because if we have this really expensive and crude product then market won't grow.

Matthew: Yeah. The price is gonna come down in one way or another. I'm just trying to imagine all the different ways it can. Can you talk a little bit about your intellectual property strategy and patents in your business and how you manage that whole thing?

Kevin: A little bit, yes. Not very much, but like maybe just a little bit. And this is like a really interesting area to kind of look at IP-wise. And there's a lot of different, you know, competition coming into this space that we're keeping an eye on. I mean, as far as like maintaining IP and having good defensible positions, it's just about like, you know, having great advisors, having people who have lots of experience who can help guide that pathway and then making sure that that's part of your work. In our case, you know, we have two patents which are published and people can take a look at. And maybe that's currently the only like public thing I should say about our IP stuff. But it's part of like, you know, maybe the plan overall to have a good portfolio and to make that part of what, you know, helps support us when we start bringing products to market.

Matthew: Okay. Do you have any traditional cannabis companies as investors for real, like licensed producers or anything like that?

Kevin: Yes, we do. One of our bigger investors overall is Organigram, which is based out of Moncton, New Brunswick.

Matthew: That's cool. You know, they're looking ahead, so that's great.

Kevin: Yeah. And they were the first ones to really make a big, you know, investment towards this kind of technology actually. And, you know, despite...I've spent a lot of time, you know, talking with a lot of different kind of these producers and they were the ones to really like step forward and make an offer. So, and now we've seen a lot more, you know, since then start to step up too. But, yeah, it's one of these areas where like if you're ahead of the game where you're starting to look at it now, then now's the right time to start looking at that and start making these relationships, right, because it's coming.

Matthew: Yeah. And where are you in the investment process right now in raising capital?

Kevin: Yup. So we are...so I guess we did close our Series A investment with Organigram in September of last year. Now, we're looking at plans for funding for our commercial development and really focusing more on like the manufacturing go-to-market strategy and stuff like that. So that's what we've got upcoming in the future. So there is definitely more fundraising in our future and then how we go about that, we're still maybe like, you know, working out a bit or I can't say too much about like, you know, our plan for that overall, but that's kind of what's coming.

Matthew: Okay. And when you look out on the horizon, let's say three to five years, what do you think is possible for cannabinoid biosynthesis?

Kevin: So many things. It's about getting this into a, you know, larger-scale situation and having like...I mean, I always look to existing industries in food and beverage or in pharmaceuticals as examples of how things should go with like, you know, product manufacturing. And right now cannabis is just like so far, you know, from what you would see for like, you know, the sugar that goes into like the typical like, you know, canned beverage, let's say, where it's something that is sourced easily in immense scales and people can really build global brands off of like these ingredients. And right now that almost doesn't exist in the cannabis world. So I think, you know, one of the first things that we'll see is that kind of normalization of the cannabis supply chain and we wanna play a big role in that and provide those kinds of like larger-scale reliable ingredients.

And then like I said earlier a bit too, there's gonna be a lot of interesting like product diversity to be introduced and really new ideas about like, you know, which cannabioids should be formulated and how they should be formulated and which, you know, pharmaceuticals can be developed from these unique formulations. Maybe not so much for the recreational market, but I think for, you know, there's a hundred cannas [SP] out there and some of them probably work better for certain diseases than other ones and we want to help with like, you know, discovering that and making that real.

Matthew: Okay. Let's jump to some personal development questions here. If for some reason you couldn't work in the cannabis industry or biosynthesis at all, in other words, if you had to do something totally different from what you're doing now, just because you think it's interesting and fun, what would it be?

Kevin: Yeah, that's a fun one. I guess, I mean for me, what really got me interested in this technology and in this, you know, I guess in the cannabis industry as a whole is how fast-paced it is and how it is this kind of like, you know, not just the new technological kind of revolution, but also this new cultural revolution where this is like the end of this prohibition and being a part of that whole like, you know, movement is so interesting. So I'd like to be part of these kinds of things that have this kind of impact and that use really interesting technologies and, to some extent, that are always gonna be like...you know, have a high technological risk because that's part of the fun of it.

I've thought about this a little bit at least where, you know, if I had a job at like a regular tech company or maybe at a company that has more established like revenue streams or that isn't using so much like of these, you know, inventions of new technologies, then I feel like I'd become quite bored maybe a bit. And then now I have to focus on these higher risk and very intense kind of challenges and probably not so good for like, you know, making money all the time because, you know, risk is hard to manage. But at least it's what I enjoy doing and I like to work in science and technology and like towards people who are always thinking a bit about, you know, how you might invent new things and create new products and be in an industry that is exciting and changing all the time. Yeah.

Matthew: Cool. And you have a maker space, which is totally unrelated to what, you know, you're doing at Hyasynth Bio. Could you talk about what a maker space is and what you have going there in Montreal?

Kevin: Yeah, definitely. That's very much a side project and yeah, don't have as much time as I would like to spend working on that. But it is a maker space so you can get a membership and you can make whatever you want there. And we have most of the tools for any kind of woodworking project at least and some metalworking and other kinds of things too, like laser cutting and 3D printing, and it's sort of born out of that movement. And it's just a fun thing to manage. And you meet a lot of really interesting people, including, I mean, some people that are coming from more like the finance world who would just wanna have a hobby and then the people who are trying to make, you know, their livings off of trade skills and will actually run their businesses out of this kind of space.

So it's an interesting, you know, side project to work on from like a business standpoint and just to gain some more experience in like different kinds of work and business models for me personally. And like, it's a social good project. So it's a nonprofit, it's co-op and, you know, I really wanna find ways to, you know, support these kinds of communities and, you know, create...I guess we're doing a lot of work with inclusivity and just making these tools more available before...I guess there's this constant issue that I hear about in the educational system now where people are getting less involved with trade skills and people are forgetting how to do woodworking and normal, like, you know, house stuff. And so we've had some of the school boards come to us and talk about like re-introducing, like, shop class kind of thing. But anyways, I'm getting into the weeds with that product to you. But it's quite fun, yeah.

Matthew: Is there anything that's anybody has made there that's kind of jumped out at you? Like, hey, wow, this is pretty cool that this was made with all the tools at the maker space.

Kevin: We've had a lot of people be interested in making guitars, which is this sort of like complicated skill that normally you go to school and spend a lot of time on, but now you've got this little guitar making club of people who are just there like every week, every Tuesday night I think, they meet up and they just go at it and make guitars and now they made some like really, really beautiful projects. And that's one of the things that...I mean it's cool to make a guitar, but if I were to think about making a guitar, I feel like it's something complicated, it takes a lot of time, and it's maybe hard to do, but I guess, you know, maybe it's not so difficult to start doing that. And part of the process of making is like the fun of actually making it and then, in the end, you have this like really, really nice product. And so that's one that I was maybe a bit surprised that like kind of took off and that, you know, we have now this like group of hobbyist guitar makers that will just work on their projects and have a lot of fun doing it because I feel like it is a bit complicated. But we have a great team that's running that. So it's awesome.

Matthew: Okay. That's cool. Here's a Peter Teal question for you. What is the one thing that you believe that most people would disagree with you on? It can be about anything, not necessarily the cannabis industry.

Kevin: Maybe I only think of agreeable things and everybody's just happy to agree with me. No, I guess, I mean there's questions about...I mean, one of these ones actually in the cannabis industry I'll specifically maybe address is this idea of the entourage effect. And the agreeable thing that I would say is that, you know, it exists. It's something that is like worth looking into and definitely there's something going on there. But I find a lot of people like use it as a sort of dismissive way to like, you know, accept that like cannabis is the ultimate solution and the end goal for everything that we ever need, which it definitely is not. Like we can define things that are better than cannabis or find specific parts of cannabis that really need and really can improve on or that will make for better medicine and so on, so forth.

So it doesn't make sense to, you know, be so centralized on like, you know, accepting that cannabis, as it is naturally, is like the ultimate solution. And so like the agreeable point I would say is like, yeah, it's part of the story where, you know, for us as a company and for the cannabis industry as a whole, you know, we're gonna find a lot of new things and the entourage effect or whatever will get more refined and we'll start to understand a bit more how these different components work together and be able to, you know, leverage that to build really interesting things. And then make the disagreeable thing that I could say is also that the entourage effect shouldn't exist or doesn't exist. Or maybe the fact that, you know, this word was even used to describe this is actually hindering a lot of maybe new science that should come into effect because people are more keen on investing more in the cannabis growing and less so in the actual understanding of this entourage effect and getting to the bottom of how these things actually work. And yeah, that's one that I sometimes get stuck on a bit, or I always get asked about it and then I usually give this kind of answer and then people are like, okay, this is good.

Matthew: No, that's controversial enough, I think.

Kevin: Yeah, yeah, yeah. So yeah, that can make me...you know, I don't think I've...maybe after a few drinks, I'll just say it doesn't exist and then be in an argument with somebody for awhile, but...

Matthew: Let's start there just for fun just to poke a bear.

Kevin: Yeah. Yeah. But I think it's one of these things that like fully satisfied with acknowledging its existence and finding ways to work with it. But I find that, you know, maybe there was a better way to approach that challenge as opposed to just kind of like, you know, accepting it and using it as a reason to not do more science. I think that's kind of silly.

Matthew: Okay. And last time you were on the show, you mentioned two books, "Future Perfect" from Steve Johnson and "Bold" by Peter Diamandis. And are there any other books that you've had an impact on your life since then that's worth talking about?

Kevin: Yeah, definitely. I've been reading a fair bit lately. So I've got maybe five I could recommend, but I'll choose maybe a couple of these. I really enjoyed "The Three-Body Problem" series from Cixin Liu. And that's like sci-fi, but it's like a being sort of recent and relevant. It's actually really, really interesting. So highly recommend that one. And then I also am really enjoying reading a bit about the modern art world in this book called "The $12 Million Stuffed Shark," and it's, "The Curious Economics of Contemporary Art," by Don Thompson. And this is like a really interesting, like, you know, discussion about like how the modern art world works and how people will kind of drive up the price of different kinds of art. And it's always this like, you know, mix of subjective judgment and personalities and everything like that.

And to some extent we see that a lot in like the startup world too where, you know, it is about valuation and about hype generation and how to like, you know, leverage that in many ways. So I like to...I'm interested in reading this book because it's a fun book to read, but also there's something interesting like, you know, tidbits about like, wait a second, you know, this kind of applies to some of the things that I do on an everyday basis. Or it kind of explains a bit of like, you know, the things that we see in the startup world.

Matthew: You know, it is similar in some regards, the modern art and how, you know, art dealers, they really try to get you into the narrative about the artist or the piece and something about it. And usually, if it's unusual or something that, you know, has some dimension to it that's fun to share, then they can kind of hook you into it. You know, like they can get you to buy into the story about the artist or the piece or why it has some sort of importance and then they're kind of hinting at maybe it's limited supply and then there's other people looking at it and in the future, who knows how much could it go for. You know, I've seen all that with art and it's like, well, you know, even though you know it's happening, it still works. Like our minds are hard wired that way to think in terms of, you know, stories and narratives.

Kevin: Yeah, yeah, definitely. And this is I mean, pitching 101. And if you look around and watch some like, you know, pitch instruction videos for startups, like they do really focus on leveraging that story and making sure that, you know, part of what you tell is it about, you know, your team and your overall story and trying to get people hooked on like this idea, right? And I mean, in the extreme cases, it goes awfully where, you know, the CEO is just kind of over-pitching and the story is too much and there's not enough like function behind it. So it's this really, really interesting, like, yeah, communication question that is funny about how like the human mind works and what we have to do in order to get each other to understand things, to focus a bit maybe. But it's, yeah, yeah, really, really interesting.

Matthew: I think about how powerful that narrative is too because, you know, Ben & Jerry's ice cream, we have the idea of the two quaint guys from Vermont and I've been to their factory up there in Vermont and it's nice and everything, but I mean, they were bought by Unilever, a huge, multinational years ago, but people still kind of have that quaint kind of idea about Ben and Jerry when they're buying ice cream, even though all of that has gone. So it's so durable once it's in people's minds.

Kevin: Yeah. Yeah, it is. And I guess that's what sticks and that's why, you know, we have brands that have value in the end, right? And, you know, I guess with Ben & Jerry's, it's enough, like, great ice cream behind it that people still love the ice cream and they still love the story. If the ice cream wasn't so good then maybe people would kind of shy away from that.

Matthew: That's true. Good point.

Kevin: But I think there has to be like this nice...I mean, in the end, you kind of have to have to deliver something. And I think that maybe in this book there's like these art pieces that maybe it's not so much about delivering on something and something feeling just about generating a lot of energy, but it's it...yeah, I mean understanding this aspect of like, you know, what attracts people to certain things is an important thing to think about. And it applies to like, you know, daily life or at least gives you a sense of, you know, how people will rationalize certain decisions. And whether it's, you know, us talking to like the Canadian government or us talking with investors or us talking to like potential customers, there's always like, you know, this goal, in the end, of trying to get people to understand and be interested in what you're doing.

And then you have to also kind of, you know, give them something functional that they can actually latch onto in the end. So it's not like a pure story and this always like maybe worries me about a bit being in this like biotechnology sphere where companies will go out and raise like tons of money. And the biggest like, you know, scandal of the decade is the Theranos company which managed to raise tons of money without showing very much technology at all. And then, in the end, their investors were totally fooled by this great storyteller, which is both unfortunate for like the wonderful storyteller that could have used her skills, like, elsewhere and also for the industry as a whole of like, you know, getting people to understand things and not be afraid of technology, I guess. So yeah, it's so many interesting, you know, such an interesting dynamic to kind of like look into and understand it. And it is also like a very funny story to tell about this shark that was sold for $12 million.

Matthew: That sounds like a great book. I'm gonna have to check that out. What's the title one more time for people?

Kevin: It's called "The $12 Million Stuffed Shark."

Matthew: Okay. Okay. Well, Kevin, as we close, please tell listeners how they can find you online at your website and also for accredited investors, how they can reach out to you if they're interested in investing.

Kevin: Definitely. The place to go is hyasynthbio.com. So that's spelled hyasynthbio.com. And for now, that's the place to go for I mean all points of contact, I guess. For now at least still, I don't know how long this will last but I do go look through all the emails that do come through that. And if somebody is interested and coming from an investment firm, that is one that I like usually pick up and will reply to. And otherwise, it's nice to hear from people just, you know, who have their different stories and if there's a relationship to be built between like, you know, us and another company you or if you have an idea then it's always nice to chat about, I guess. So I encourage people to come out and reach out to us.

Matthew: Great. Well Kevin, thanks so much for coming on the show and educating us today. This is a really interesting area, biosynthesis, so we'll watch closely as this proceeds and come back and give us an update sometime.

Kevin: Yeah, definitely will do. I would love to be back sometime.

Matthew: If you enjoyed the show today, please consider leaving us a review on iTunes, Stitcher, or whatever app you might be using to listen to the show. Every five-star review helps us to bring the best guests to you. Learn more at cannainsider.com/itunes. What are the five disruptive trends that will impact the cannabis industry in the next five years? Find out with your free report at cannaninsider.com/trends. Have a suggestion for an awesome guest on "CannaInsider?" Simply send us an email at feedback@cannainsider.com, we'd love to hear from you.

Please do not take any information from "CannaInsider" or its guests as medical advice. Contact your licensed physician before taking cannabis or using it for medical treatments. Promotional consideration may be provided by select guests, advertisers, or companies featured in "CannaInsider." Lastly, the host or guests on Canada insider may or may not invest in the companies entrepreneurs profiled on the show. Please consult your licensed financial advisor before making any investment decisions. Final disclosure to see if you're still paying attention, this little whistle jingle you're listing to will get stuck in your head for the rest of the day. Thanks for listening and look for another "CannaInsider" episode soon. Take care. Bye-bye.

 

Ep 278 – Global Cannabis Trend: Exporting Extract From Africa to Europe

jonathan summers exmceuticals

It’s no secret cannabis cultivation is going global. Here to tell us why and how he’s expanding into Africa is Jonathan Summers of EXMceuticals, a medical cannabis firm that aims to become the largest volume, lowest cost producer of wholesale cannabis in the world.

Learn more at https://exmceuticals.com (CSE: EXM) (FSE: A2PAW2

Key Takeaways:

  • Jonathan’s background in cannabis and how he came to be Executive Chairman of EXMceuticals
  • An inside look at EXM and its mission to become the largest volume, lowest cost producer of wholesale cannabis ingredients
  • Jonathan’s insight on Brexit and how it will affect London as a financial hub
  • Why EXM cultivates cannabis in Africa before processing, selling, and distributing in Portugal 
  • What cannabis cultivation in Africa could mean for the country’s economy and job market
  • Differences between the cannabis industry in Europe versus the U.S. 
  • The products Jonathan foresees gaining traction in Europe over the next few years 
  • What Dixie Elixir’s Tripp Keber is bringing to the table as a strategic advisor for EXM
  • How EXM is working to support African communities through nonprofit funds and increased employment
  • Inspiration Jonathan draws from lectures given by English philosopher Alan Watts
  • Where Jonathan sees EXM and cannabis heading in the next few years
Click Here to Read Full Transcript

Matthew: Hi, I'm Matthew Kind. Every Monday look for a fresh new episode where I'll take you behind the scenes and interview the insiders that are shaping the rapidly evolving cannabis industry. Learn more at cannainsider.com, that's cannainsider.com. Now, here's your program. It's no secret that cannabis cultivation has gone global. Here to tell us why and how he's expanding into Africa is Jonathan Summers, chairman of EXMceuticals. Jonathan, welcome to "CannaInsider."

Jonathan: Great to be here. Thanks, Matt.

Matthew: Give us a sense of geography. Where are you in the world today?

Jonathan: Right now I'm sitting in beautiful, sunny London. I'm watching the rain come down. And the reason I'm in London is where cannabis business mainly operating in Africa and in Europe.

Matthew: Okay. And what is EXMceuticals on a high level?

Jonathan: EXM is best thought of as an ingredients business based on CBD and individual cannabinoids.

Matthew: Okay. Can you share a bit about your background and journey and how you got into the cannabis space and became part of EXMceuticals

Jonathan: Sure. My pleasure. It was...a few months ago, I've always been in finance. So I managed to do 15 years as a Wall Street banker before I left and did a couple of more entrepreneurial things in asset management. Started a couple of hedge funds, asset management businesses. And towards the end of last year, I began to look around for something else, having done finance for well over 20 years. And a friend originally brought me the EXMceuticals as a company he had met and was interested in and was helping to raise some small money for them. And he recommended I met them and I did so. And frankly, was very impressed with the plan.

I also thought that there were a number of things that possibly they weren't doing that maybe they should have been doing. And I started asking lots and lots of questions in addition to investing a small amount of money. And as part of the process of me asking lots of lots of questions, which tends to be my way, I got to know the guys who are running the company very well. And about six weeks later they asked me to come on board in an executive capacity. And that was end of May this year and I've been the executive chairman ever since.

Matthew: Okay. What do you think about Brexit? I mean, how do you think that's going to affect London as a financial hub? I mean, I don't really know. I spend a lot of time over in the UK, but I think, "Hey, perhaps if there's a clean break for the UK, you know, there could be more desirable tax rates and more business would flow to the UK be taken out of the European Union." I know there's more considerations and variables than that, but what are your thoughts around that?

Jonathan: I think it's one of those...we're kind of in uncharted territory, everybody feels very passionate in terms of their views which range vary widely from one end of the spectrum, it will be a disaster to the other end where people think it will be a fantastic boost to the economy. I think the truth will probably lie somewhere in between, but the facts are that this has been pending now for well over three years. A lot of the slowdown in economic activity that you would expect when there's a big change like this has already happened. For example, central London property prices are probably down 30% in the last 3 years as people have been worried about Brexit. So I would imagine that if Brexit is something other than a complete disaster, you would see, if anything, activity in London and England pickup.

Matthew: Yeah. Okay. And what do you think of Boris Johnson's haircut?

Jonathan: I'm a big defender of Boris, not necessarily as haircut, but because he's written a couple of very good history books, I would probably give him the benefit of the doubt.

Matthew: Okay. You've got some wild haircuts over here too. So that's...I understand.

Jonathan: You haven't seen mine yet.

Matthew: Okay. Let's talk about Africa a little bit. Why did you choose Africa and where are you operating there?

Jonathan: Sure. So just to give some background, Marc Bernier, the founder of the company, this is nearly three years ago now. So, a long time before I got involved. He was quite early in the evolution of cannabis and industrial hemp. He was working on a couple of projects in the Caribbean where he was setting up businesses and very close to having licenses and for various reasons based upon the scale of the land that he could cultivate, and just sort of the footprint he could develop he decided not to proceed with those, and the company then moved on and sort of went to Africa. The thesis behind all of it, but where Africa particularly was where we wanted to build a business with is basically you want to grow cannabis where it grows naturally. You want to grow cannabis where it's hot and sunny, ideally pretty much all year, outside of the rainy season, you want to go to cannabis with as long sunny days.

Lots of sunshine and also where you can get lots and lots of fertile, flat and available land. And Africa ticked the box on all those. The essential premise being you want to grow cannabis where you don't need to build large greenhouses and heat them because outside the greenhouse it's very, very cold. So that's the basic thesis behind why Africa. In terms of where we're operating, we have farms in Uganda and the DRC and we are in the process of the final stages of the acquisition of a gigantic farming and processing unit in Malawi. So that's currently where our farming operations are at.

Matthew: Okay. And DRC, is that Congo? Democratic Republic of Congo? Is that wat it is?

Jonathan: It is indeed. And obviously, when you mentioned the DRC, people raise eyebrows. It has a relatively checkered past. We are in a part of the DRC which is a much, much more stable. It's actually called the cubic [SP] kingdom. We are operating in a part of the DRC where I would imagine if we weren't there, none of the people that we're employing, of which about half of women would have a job. Effectively what we have in the DRC is a large area of clear land with a fence around it. We've put in the wells, we've put in the farm buildings, equipment, etc. And we have about 200 hectares of cleared land that we are planting out the initial 25 hectares of cannabis on. So, that's where we are in the DRC. It is basically a farming operation.

Matthew: Okay. And what markets do you think you'll be exporting to the most?

Jonathan: So we are not planning...this is important. We're not planning on exporting cannabis in any way, shape or form to countries or operations or companies outside of Portugal. So, everything we produce will be transshipped to Portugal in full client concentrate form. So we'll do the initial extraction in country. And Portugal is really the hub of our operations, which is where we are imminently expecting our initial sort of R&D pilot refinery license. And as soon as we get that... It's been about a two-year process to get to this point. As soon as we get that, hopefully in the next few days, we will immediately begin the process of fitting out and planning for a much larger to be GMP approved facility that we've already rented the site for about half an hour south of Lisbon. So right now we have an initial R&D lab and refinery in Lisbon. Once that's licensed, we will immediately begin the process of moving the refinery to the larger business facility half an hour south and the existing facility will just become R&D.

Matthew: Okay. Lisbon's becoming a bit of a hub, I know Tilray has a footprint there too. Why do you think Lisbon is kind of becoming a hub for cannabis or why do you find it desirable?

Jonathan: I think that the Portuguese authorities, while they're being very diligent, I think they're trying to build a business. I think they're obviously looking to create jobs and infrastructure in the country. They are gradually liberalizing the codes around marijuana, although obviously purely recreational is still frowned upon. I think that, you know, for example, I heard the other day 45 licenses are currently going through the application process to grow cannabis in the country. And that's obviously a process where we can be part of that because we're not going to be growing in Portugal, but we'll be very happy to process other people's production, you know, on a commercial basis.

Matthew: Okay. I'm curious how the African government officials have reacted to the prospect of cannabis cultivation in their borders. I mean, they haven't had the propaganda and reefer madness that's gone on in most of the Western world. What's kind of...what's their orientation in terms of how they feel about cannabis?

Jonathan: I think it's mixed. On one hand, there's an obvious slight nervousness. There is obviously a negative association within the country to do with, you know, with some people with recreational use, somewhat frowned upon there. So I think where they are generally much more encouraging of it is where it's an export market product where you're cultivating in the country, ideally transforming, doing some extraction in the country. So it's not just a farming operation. And then transshipping it elsewhere for medical or nutraceutical purposes, I think they have a lot more time for, I'm not sure there's a huge drive at the moment for sort of in-country distribution, and really in many cases the plant grows wild there anyways. So I'm not sure that's a process which you could really want to distribute in-country. There doesn't seem to be much point to that. Where I think this really resonates with governments, certainly in sub Saharan Africa, is in terms of job creation, export revenues because one of the big crops in a number of these countries, particularly in Malawi has been tobacco. And as the tastes, needs, wants, desires and the health issues of the world evolve, tobacco is a crop, which frankly is in less demand.

And with the price down, something like 50% for certain kind of...sorry, for certain tobacco strains in the last 2 to 3 years, the farmers are looking around for something else to grow and the local governments are looking around for other sources of revenues. It's that simple.

Matthew: Okay. So you're growing outdoors, taking advantage of the sunshine and eliminating that electricity costs. Is there some greenhouses involved there or is it just pure outdoor?

Jonathan: So I think it would be...it's not smart to just have a purely outdoor grows. So obviously we have nurseries, we have one in Uganda and a very, very large 10-acre nursery, comes with the facility that we're buying in Malawi. And in the nursery you'll keep your seed stock, you'll keep your basic plants and you'll take cuttings from and your plant out from there. And then maybe you plant out in the field when the plants are a few inches, maybe a foot high on that basis. But I think it would be...it's not as unsophisticated as just scattering seeds in the field. We're going to be looked at plants out of the nursery. One of the things we are doing in all of these geographies is also figuring out what we'll grow well outside in these environments that contains a lot of CBD. So for example, it wouldn't come as a surprise to you that a lot of the local strains in some of these countries are very high in THC and don't contain a lot of CBD. Also some of the more, shall we say, heavily engineered genetic seed stock that's just been bred in the West or in Canada to produce CBD doesn't necessarily grow that well outside in Africa given the environment. So, there is a process to go through in terms of what grows well that contains the right ingredients.

Matthew: Okay. So, you don't plan on selling flower, just concentrate and you're going to extract into concentrate there in Africa then export it. Talk a little bit about the strategy there. Is it really just to try to get as much value per gram over or what's kind of the idea there?

Jonathan: Yeah. I mean, it's really based upon...we're in ingredients business. We're not in the business of selling flowers for medical reason or for any reason. And I think it's, you know, what we'd like to do is very rapidly to get to the point where we're putting a lot of production through the extraction facilities. We already have a fully built one in Uganda and we will be putting one in Malawi as soon as we are able. You want to put the biomass in there as soon as you possibly can after you harvest it to keep as much of the sort of CBD chemicals as you can, the terpenes, etc., which we can also talk about and get that into a container and get it shipped to the refinery in Lisbon. This is really about growing biomass, leaving the biomass in Africa and we can figure out what to do with that further down the road. But getting the sort of the concentrate, the chemicals to the refinery as quickly as possible.

Matthew: Okay. So how much do you anticipate getting to the Lisbon refinery out of the gate?

Jonathan: So, our numbers for next year include us having 100 hectares of cannabis being cultivated all year. We're assuming that we can produce three crops because it would probably be slightly more than that, effectively as a three-month growing cycle. But you don't really want to be growing in the rainy season. The countries we've chosen, the rainy seasons don't overlap. So effectively we'll be able to grow all year. But obviously, while we're talking very, very large amounts of land, we're obviously not going to be plotting it all out initially. But if I give you an example, one hectare of land, fully planted and these plants get quite large when they grow outdoors in Africa, so they can easily be eight feet high. We're talking roughly 10,000 plants per hectare. If you assume that habitat produces 3 crops a year, and again, we have no shortage of land and roughly 6% of that, biomass turns into eventual sellable isolate or distillate, each hectare producers just over 7,000 kilograms of sellable product a year once it's been through the refinery. So effectively, if you think about it on a modular basis, if 1 hectare produces about 7,000 kilograms and you've got 100, 200, 300 in the ground, you can just do the math.

Matthew: Yeah. Okay. This is interesting. What kind of finished products do you anticipate the ingredients will make there the most? What do you think are the top three will be people use the ingredient for after it's refined?

Jonathan: So, I think Europe is very much in its infancy here in terms of where this product goes. And the vast majority of the 700 million Europeans that are getting excited about CBD are currently either thinking of purchasing or purchasing oils or tinctures. The U.S. has obviously ahead of this. And over in California, there's a lot of cannabis brands, be them CBD or recreational THC. So I think over here it's kind of in its infancy, but in general, I think obviously oils will be a big one initially, but the market will move on. I think nutraceuticals could be very big. Things like sports recovery, creams, hand creams, cosmetics. I think longer-term beverages and particularly food will need to be slightly further down the track, obviously given the regulatory burdens that are on that. And rightly so, given you need to make sure that the products are pure and to an extent, say, do what they say they're going to do. But I think in the short term it will be a sort of a nutraceutical market, a wellness market.

Matthew: Okay. And what about the minor cannabinoids like CBN and CBG? And maybe talk a little bit about terpenes and how you plan to preserve those two, if you would.

Jonathan: Yeah. So look, I think this is very exciting. I mean, at the moment, I think the point is everybody is fixated upon CBD. You're right to ask the question about CBN, CBG, THCV, etc. All these cannabinoids I think will really be a focus and it's going to be a focus for us. It is a focus for us. I mean, we are really aiming to produce 99.99% pure cannabinoid isolates from what will be a GMP facility. I think the market will increasingly mature towards a point where people will want specific cannabinoids because as the science proceeds in terms of what cannabis is used for or can be used for, people will want that particular effect. The science of the plant is really not very well understood right now. It's obvious that it does something, it needs to be a lot more quantified. The basic... As the science finds out what these individual cannabinoids do, it may well be discovered that certain combinations cancel each other out and other combinations enhance each other. So I would imagine very rapidly, and I think within a year or two you're going to get specific users will want to purchase large amounts of individual cannabinoids. And I think obviously CBN and CBG are the two you've asked for, specifically much in demand for sleep.

Matthew: Yeah. That makes sense. How do you find the posture or sentiment in the UK is changing in terms of adults talking about cannabis and maybe they're starting to look at it differently?

Jonathan: So, I think the problem that we have over here is a problem that maybe is general in cannabis. What would the fact that the industry is so young and has really exploded in the last year? I mean, I'll be honest, six months ago before I first came across EXM, I was really very uninformed about CBD and cannabis and medical and recreational. And I would've been asking silly questions too. The media generally doesn't understand it. I was at a conference recently where I was talking about EXM as an ingredients business and we're focusing on CBD and wellness. And the first question I was then asked was, what did I think the timeline was for cannabis to be legalized? At which point I said, "Well, CBD already is." And I had a sort of a blank stare back. I think there's so much confusion, so much confusion and misinformation and misunderstanding.

Not all of it deliberate, a lot of it genuine because people just don't understand the industry. Some of it I think in the media is created to sort of sell papers, etc. But so many articles about CBD ended up getting bogged down in discussions about recreational cannabis, which, look, if with CBD legal in the UK, if...you know, as long as you supply products with less than a very, very small amount of THC in it, I don't care if cannabis is never recreationally legalized, we can still build a very large business in the UK. And the UK is just one country out of many in Europe.

Matthew: You recently announced Dixie Elixirs founder, Tripp Keber as a strategic advisor. Tripp has a deep background in North American infused products, but how was he going to help with the EXMceuticals?

Jonathan: So, it's really three-fold. So, the most obvious way Tripp will help is, Tripp has been involved in cannabis for 11 years through various ventures. Obviously the biggest one being Dixie. He grew up in the space. He's seen it evolve. He knows a lot about the industry, the business, the plant, you know, in addition to that, you know, I'm a finance background. My COO is a finance background. We have obviously a visionary founder. We have, you know, farming staff, but we haven't got somebody who's really grown up in cannabis. And I think Tripp sort of clearly ticks the box there. I think Tripp also knows a lot of people. I mean, Tripp is an incredibly sociable individual. He knows the vast majority of people that are active in the industry, particularly in the U.S. He can make lots of connections for us, and indeed already has.

And he and I were in the States two weeks ago. We attended the conference in New York, which was fantastic to spend both time with him, but also with a lot of the people that he knows. In many cases, these people have built great businesses or done a lot of investing in the space already over the last two or three years. The last place that Tripp can help us is a very, very key one. And that's one of the initiatives that the EXM is currently working on is we've had an MOU where the Canadian company called GFR Pharmaceutical for the last 18 months. And we are currently in the process of turning that into a firm and binding 50/50 JV. GFR is Canada's biggest white label nutraceutical company. They own an operator, state of the art facility just outside Vancouver, producing and selling hundreds of millions of Canadian dollars of non-CBD related nutraceuticals every year.

They obviously supply a number of very, very big clients. A lot of their clients are telling them that they would like to get into full-spectrum hemp boilers or CBD. So obviously GFR has a desire to get into that business too. We will supply our 50/50 joint venture with very reasonably priced low-cost production full-spectrum hemp boilers CBD from Africa via Lisbon. We will also put Tripp into that JV. Tripp is going to be on the board of that. And we're going to buy, build or lease a factory facility, most likely in Colorado, which is where Tripp is based, but it could be Arizona. And we are going to build, create a state of the art facility to do white labeling for CBD products around the U.S. And, you know, the reason why Tripp is excited to be with us is he understands the EU GMP from Lisbon with the cheap production from Africa. But also he's met the GFR guys. He's visited their family...sorry, their factory, he hasn't visited their family. And we want to build a state of the art facility in the U.S. to take this to the next level and really do this on an industrial scale. So, Tripp is key for our ambitions in North America. But the connectivity he has his in the industry is second to none.

Matthew: And tell me, what are you doing there with the local community in Africa? We talked about the government officials, but how about the people that work at facilities and the local community there? Because I'm sure that means it's not only good for business but, I mean, it just helps the world in general. And I know you're doing some things there, but I don't know all the details.

Jonathan: We're trying to...I think we're trying to do things the right way. So for example, we already talked about the DRC. There was a several month period late last year and earlier this year when we weren't producing any cannabis because for various logistical reasons, we had to put some wells in and we were spending CAPEX because we'd grown a very small amount prior to that. We had the staff, again, half of them are women. We didn't lay them off. We kept paying the wages. I doubt these people would get another job in the region that they live in without us. That's just an example of, I don't think you can just turn the wages on and turn the wages off because people rapidly come to rely upon it. Specifically in Malawi with the unit that we're buying, it's a very large agric processing facility with 2000 hectares of land.

The factory that comes with it is state of the art. It's like something you would see in Atlanta or in the UK. Two hundred and twenty employees going up to 300 in the harvest season for mangoes. It's currently a mango plantation. You know, I think it's fair to say that those jobs would not necessarily be existing in a year or two if we one coming in to sort of turn it into a...also into a cannabis cultivation facility. For the record, I'm not going to rip the mangoes out. Why would I? It's fantastic. We're one of the biggest mango plantations on the planet. So, we'll keep those, but we'll be looking to scale up. We'll be looking to preserve and scale up the 220 jobs there. But also I think what you're referring to him as across everything that we're doing in all of the geographies we're operating in, 2% of the revenues from the local operation will be sort of segregated out and sourced and given to a local trust.

There will be a board for the local trust. But effectively the local people will choose the projects that money is spent on. And I would fully expect that to be projects that fit with the needs of the local community. Now, it's pretty obvious that particularly in the DRC and Malawi you can do less so, but particularly in Uganda...sorry, the DRC and Malawi, we're dealing with very poor countries here that they need the export revenues, they need the jobs and they need money to be spent.

Matthew: Yeah. That makes a lot of sense. That's great. I watched this really closely, this international cannabis trade, because it's, you know, it started out with a trickle, you know, with some businesses moving down to South America and Columbia because it's such an ideal growing environment in the background for flowers. And, you know, now what you're doing with Africa and it makes a lot of sense. I mean, this is happening with other, you know, agricultural products, why not do it with cannabis as well? I mean, much more profitable plant. But then I think about, okay, in the Netherlands they are incredibly efficient and productive with these greenhouses. But still, I don't know what kind of the tradeoffs are in terms of how much profit they can make and the efficiency at their greenhouses indoors. But I got to imagine that somehow there's going to be some point where these all these things kind of compete with each other. Like these really high-efficiency greenhouses like the Netherlands. What you're doing in Africa, what's happening in Colombia. So, I assume at some point there's going to be like a...just like there is for pork bellies or soybeans, kind of like this international price that...maybe that'll be for hemp first, but maybe then for certain cannabis strains where there'll be futures contracts and so forth. Do you have any thoughts around there?

Jonathan: I would completely agree. I think it's going to become an industrial crop, whether it's cannabis or industrial hemp, it'll take slightly longer for cannabis to be an industrial crop because it's harder to grow legally, but industrial hemp rapidly will become an industrial crop, it goes without saying. I think you have to be looking to... I don't know if we're going to be the lowest cost producer, but we're certainly not going to be the highest. I think if the price, I would predict the price, particularly for industrial hemp will come down significantly over the next 24 to 48 months, maybe even sooner. But because we're growing without the big CAPEX and without heating facilities and because we can grow all year, our production costs per plant or per unit, how do you want to quote it, per milligram of CBD, etc., will be, I believe some of the lowest and it's not going to be a race to the bottom, but it will be something of a race to the bottom.

But I know a lot of other people will not be able to produce at the levels we can produce. And if it gets to the point where we're not making money in our farming operations, I'd say that the vast majority of the industry aren't either. So look, I would agree. I think if this was just about cropping and growing cannabis, it's less of an exciting proposition. We are, you know, we're not just growing. We're also in the process. We have the CBD refinery and the R&D lab in Lisbon. We have the joint venture in the U.S. which I think gives us a lot of credibility. And to have, you know, fast forward six months and EU UGM GMP approves facility, half an hour South of Lisbon capable of processing all kinds of extracts from all over the world I would say would be a massive differentiating factor.

But when I think about the price of wholesale ingredients coming down, the price of biomass coming down, lots of people growing cannabis and hemp. In a way this is inevitable. And if you think about how CBD and cannabinoids really become a multi, multi, multibillion dollar industry, I think prohibition partners think 28 billion pounds a year by 2028 in the UK. So, if you assume that happens, the price point and the price at which this can go in things has to come down in order for it to be a mass-market adoption. So, for example, if you're talking about CBD, going into beverages is probably not going to happen when the price of wholesale CBD is where it is now, because it would put the price of those beverages up too much. But if the price comes down, you are much lot more likely to see mass-market adoption on a gigantic scale, which would sort of just massively increase the volumes. So look, I think the price coming down means that you need to grow cheap, but the...or produce cheap, but the price coming down will also mean that the take up of the product explodes even potentially as quickly as the most optimistic estimates.

Matthew: Okay. So the market expands as the margin potentially sink or lower. So you're making up in a revenue here even though you're losing in profit a little bit.

Jonathan: Absolutely. I just think...but if I think in terms of competitive advantage, growing outside on massive areas of flat land in Africa, eight-foot-high plants grow all year. You know, even if I automate my Dutch greenhouse or my Canadian facility, you know, there's no way you're going to be able to compete with that for nutraceutical general ingredients, which is what we're competing in. If you want to grow very high tech, purely medicinal cannabis, where each plant is barcoded, yeah, you'll need to do that in a greenhouse. If you want to grow specific strains of recreational cannabis to supply to a particular group of consumers who wish to consume it, that again needs to happen inside a greenhouse. That neither of those are businesses we're going after.

Matthew: It seems like, I mean, in many ways that Africa and, you know, there's a lot of individual countries in Africa and they're very different, but, I mean, they have no legacy infrastructure. So you can see kind of the uptake of certain advanced technologies like M-Pesa is a payment system there where, you know, if you have a cell phone, you can send money around anywhere in Africa. And I can't remember which telecom provider, I think it's a UK telecom provider that provides that service and they're putting them land deeds on the blockchain in certain countries in Africa. Do you see kind of catapult effect of Africa kind of going slow, slow, slow, slow and then like boom, making massive leaps to kind of get catch up to the developed world?

Jonathan: I'd like to see that. I think, I mean, we're a profit making enterprise. We're a company, but, you know, it would be nice to do some good as well. I don't know exactly how growing cannabis in Malawi, for example, is going to speed that up. But I completely agree with what you're saying. So for example, the best one is mobile telephones. So the fact that no outside of South Africa, no African country really built out a wire line business. They skip that. They completely ignore those billions of dollars of CAPEX that needed to build the telephone lines and put little cables in the ground. And they just went straight to the mobile and then it sort of...they skipped that whole sort of 40 years of digging pipes in the ground. Exactly how that would transfer to cannabis, I'm not sure.

I think, you know, it would be at the very least, a good simile would, in terms of how this can really work, if you just look at where tobacco is grown commercially, it's effectively probably the same kind of places that cannabis would grow pretty well commercially. And the one soundbite that actually I got from a conference when I was in...the one New York two weeks ago. Because people say, "Look, it's going to be a similar thing as to what happened to roses." Roses used to be grown in California. Now they're all grown in Ecuador. And actually over in Europe, they're all grown...sorry, in Europe they're all grown in Africa, mainly Zimbabwe and they're shipped to Holland and that's all from Holland. So, the same sort of thing will happen in the cannabis production chain as has happened in other agricultural goods.

Matthew: Okay. Yeah, I was kind of wondering if their local population in the next couple of decades is going to start to have more disposable income where they can buy some of these cannabis products at an affordable price point. I mean, it's speculation, hard to say, but...

Jonathan: It is hard to say. I think we're approaching this very much from the point of we will extract and take the product out of the country. And the main reason why I'm thinking along those lines is that's very much what these countries want in terms of export earnings. So, there's not really been much discussion about creating domestic products at this time.

Matthew: Okay. Jonathan, I'd like to ask a few personal development questions to help listeners get a better sense of who you are.

Jonathan: Oh, do you?

Matthew: Is there a book that's had a big impact on your life or your way of thinking that you'd like to share?

Jonathan: Ah, man, that's a tricky one. I read a lot. Actually I haven't read so much in the last few months because I've been so incredibly busy and I've barely seen any of my friends, but so I haven't had a huge amount of spare time. The first book I ever read when I was...that I really remember when I was nine that affected me was "The Lord of the Rings." And I read that in about a week and I then read all of his other books and it absolutely blew me away, as you can imagine, as a young boy, age nine. That was incredible. Reading has have always been a big part of my life. I studied history at university. I was fortunate enough to be allowed to go and effectively read history books for three years, which was absolutely fantastic. And I specialized a lot in history, military history, particularly a lot of World War II, which I still find fascinating to this day and still read a lot of. Evelyn Waugh, Douglas Adams. I've read all of this. You know, books about the universe, I find fascinating. Actually, most recently, the thing I've been listening to, particularly when I'm in the car and listening to podcasts is I've been listening to a lot of the audiobooks by a 1960s English philosopher called Alan Watts. I don't know if you [inaudible [00:35:16].

Matthew: Sure. Yeah. There's a lot of YouTube videos of his lectures and stuff too.

Jonathan: Fantastic. And I think, for a start, he's got a very entertaining baritone voice, and a fantastic English accent that's way, way, way ahead of his time given he died in the late '60s. And anybody who's not listened to any of those YouTube interviews or recordings of Alan or listened to any audiobooks, I would strongly recommend a couple of hours of your time.

Matthew: Yeah. I'll put a YouTube playlist of Alan Watts stuff in the show notes so people can listen to those because I find myself YouTube suggesting those to me all the time. And I will tell you, he definitely was out of his time.

Jonathan: Exactly. Fascinating man and quite an interesting life as well. So, worth just reading the Wikipedia page on it too.

Matthew: Here's a Peter Thiel question for you. What is the one thought you have that most people would disagree with you on?

Jonathan: Judging by the fact that the EXM share price is $1.35, I would say most people would disagree with me that EXM is going to be $1 billion business.

Matthew: Wow. That's great. That's a good look into the future here. So, good points here. Before we close, can you tell us the ticker symbol and the exchange where EXM is traded?

Jonathan: Yeah, of course. The main listing is in Canada. We're listed on the CSE. The ticker is EXM. We're also listed in Germany. We're on a few exchanges. The main one has got the catchy ticket of A2PAW2, so that's where we are.

Matthew: A2PAW2.

Jonathan: Yeah. It trades in euros in Frankfurt and also in Canadian dollars on the CSC. The EXM.

Matthew: Well, Jonathan, thanks so much for coming on the show. Really appreciate it. And good luck with everything you're doing in Africa. That's really an ambitious project you have going on.

Jonathan: Thank you very much. The opportunity to come and tell you a bit more of our story, I really appreciate it.

Matthew: If you enjoyed the show today, please consider leaving us a review on iTunes, Stitcher, or whatever app you might be using to listen to the show. Every five-star review helps us to bring the best guests to you. Learn more at cannainsider.com/itunes. What are the five disruptive trends that will impact the cannabis industry in the next five years? Find out with your free report at cannainsider.com/trends. Have a suggestion for an awesome guest on "CannaInsider," simply send us an email at feedbackatcanainsider.com, we'd love to hear from you. Please do not take any information from "CannaInsider" or its guests as medical advice. Contact your licensed physician before taking cannabis or using it for medical treatments. Emotional consideration may be provided by select guests, advertisers, or companies featured in "CannaInsider."

Lastly, the host or guests on "CannaInsider" may or may not invest in the companies entrepreneurs profiled on the show. Please consult your licensed financial advisor before making any investment decisions. Final disclosure to see if you're still paying attention, this little whistle jingle you're listening to will get stuck in your head for the rest of the day. Thanks for listening and look for another "CannaInsider" episode soon. Take care. Bye-bye.

Ep 277 – Enhancing Cannabis at a Molecular Level with Biotechnology

ronan levy trait bio

What happens when biotechnology and cannabis collide? Here to answer this is Ronan Levy of Trait Bio, a biotech company that just cracked the code on how to create flavorless, water-soluble cannabinoids – and without using nanoemulsion. 

Learn more at https://www.traitbio.com 

Key Takeaways:

  • Ronan’s background in cannabis and how he came to start Trait Bio
  • An inside look at Trait Bio and its mission to make hemp and cannabis into purer, safer products 
  • The value of water-soluble cannabinoid products and where Trait Bio is in the process of achieving this
  • The risks versus benefits of using nanoemulsion in the manufacturing of cannabis products 
  • Glycosylation and how Trait Bio is using this instead of nanoemulsion to create water-soluble cannabinoid products
  • How trait amplification works to increase the yield of cannabinoids in hemp and cannabis plants
  • Trait Bio’s work with minor cannabinoids and why the industry is beginning to take more interest in them
  • How yield differs between yeast and trait application
  • Ronan’s long-term goals for Trait Bio and where the company currently is in the capital-raising process
  • Where Ronan sees biotech and cannabis heading in the next five years
Click Here to Read Full Transcript

Matthew: Hi, I'm Matthew Kind. Every Monday, look for a fresh new episode where I'll take you behind the scenes and interview the insiders that are shaping the rapidly evolving cannabis industry. Learn more at cannainsider.com. That's cannainsider.com. Now, here's your program.

What happens when biotech companies start focusing on creating compelling solutions for cannabis? Here to help us answer that question is Ronan Levy from Trait Bio. Ronan, welcome to CannaInsider.

Ronan: Thank you. Happy to be here.

Matthew: Give us a sense of geography. Where are you in the world today?

Ronan: Right now I am in Toronto, Ontario, which has really, kind of, become the epicenter of I think many things cannabis industry-related given the financial markets have largely been situated here. But this is where I've been for the last 20 years and this is where I call home.

Matthew: I would agree with that. I've noticed a trend away from some other U.S. cities and interviews I do where I'm getting more guests in Ontario. So that's definitely a trend that's going on.

Ronan: Mm-hmm.

Matthew: Ronan, can you share a bit about your background and journey, and how you got into the cannabis space?

Ronan: Yeah, absolutely. So I'm a lawyer by training, but I've been an entrepreneur by spirit for many, many years. And when I met the group of people who would eventually become my business partners, they were exploring an opportunity in the cannabis industry. And they were concerned about some reputational industries to get involved in such a nascent and little-understood industry, just given my nature of being somewhat contrarian and risk-taking.

Matthew: What is Trait Bio at a high level?

Ronan: At a high level, Trait is one of the, if not, the leading cannabis biotech companies. We are focused on solving some of the most interesting challenges and therefore opportunities in the cannabis industry. And we have a great team of researchers who are leading the way on that.

Matthew: Okay. Talk a little bit about water solubility, if you will, and what that means. And why are people even considering making water-soluble products? What's, kind of, the big value proposition there?

Ronan: Yeah. So cannabinoids, by their nature in the plant, are fat-soluble, which means they mix well in oils but not necessarily water-based medium, so water, juice, anything along those lines. And so the fact that it's fat-soluble creates challenges for a number of reasons. For one, it affects the bioavailability and absorption of cannabinoids. And secondly, from a product perspective, it's a lot harder to work with fat-soluble, essentially oils, to mix them into different products whether that product is a beverage, an edible, a vape or anything along those lines. It's just, it's more challenging. It requires high-intensity extraction to get fat-soluble cannabinoids out, often using toxic solvents. It creates separation issues. There's just a whole bunch of issues that go along with fat-soluble cannabinoids.

So there's a heavy amount of interest in water-soluble cannabinoids because it gets around a lot of the limitations with fat-soluble cannabinoids. You get faster onsets, better bioavailability. It's very easy to work with water in terms of formulation in products or water-soluble cannabinoids. In terms of formulation in products, you don't have to use other technologies like nanotechnologies, which have their own health risks to try and formulate products. There's just a whole number of benefits that go from water solubility and water-soluble cannabinoids and that's why we're focused on it.

Matthew: Can you just, kind of, mention what you're thinking with the nano-soluble risks there, what risks those pose?

Ronan: Yeah, so, nanotechnologies, there's utility to nanotechnologies. And I'm not going to suggest that there's not a reason to invest in nanotechnologies and the effort around them, which is they have great utility. But they also have limitations, which is, you know, for one thing, nanotechnologies and nanoemulsions, they can cause molecules to cross the blood-brain barrier, which when you're trying to develop cancer medications to target brain tumors is a highly effective, very desirable outcome.

But when you're looking at products like CBD and wellness products, which people are taking potentially for less dramatic health issues than, say, brain cancer, the risks associated with nanotechnologies are potentially large. They cross the blood-brain barrier, they can get into other organs like your thyroid, there are concerns around bioaccumulation, cytotoxicity, any number of potentially very concerning things that can result from nanotechnologies.

So when you look at them, and really, I think everybody has to do a cost-benefit analysis of whether the benefit associated with using nanotechnologies particularly in ingestible cannabinoid products, outweigh the risks associated with them. And, you know, from my personal perspective, and as a company perspective, we concluded that the risks certainly don't outweigh the benefits for cannabinoid products, at least as, you know, cannabinoid products are currently formulated. If it gets to a point where there's efforts in terms of drug development and real therapies that are evidence-backed in terms of treating other conditions, then certainly, it may make sense. But for general recreational and wellness products, to us, the balance certainly favors not using nanotechnologies.

Matthew: Okay. And so for a dissolvable cannabinoid solution, what do you think is the most desirable product? Like, if could wave a magic wand and solve the liquid solubility problem, where do you think the biggest promise is for in terms of creating products that the market wants?

Ronan: You know what? I don't have an opinion on what the market wants. The market is going to be driven by consumer preferences. I've always believed and having spent a lot of time in the cannabis industry, that there's going to be a strong demand for cannabis beverages. It's a form of ingestion for products that we're comfortable with that much of our social interaction has been built around.

And you haven't seen a whole lot of growth in cannabis beverages and I think that's for two primary reasons. One is, by and large, they don't taste very good presently or manufacturers have to use techniques to try and cover the taste associated with cannabinoids, at least fat-based cannabinoids or fat-soluble cannabinoids.

And secondly, because of the unpredictability of onset with fat-soluble cannabinoids, that when you ingest it, there's something called the first-pass effect, which essentially means that your liver has to metabolize that cannabinoid when ingested orally, which leads to the significantly delayed effect. You know, sometimes it's 45 minutes. Sometimes it's an hour. Sometimes it's two hours. And what too often happens is that people will ingest too much of a beverage or an edible and have a bad experience because they've consumed too much, no different than with alcohol.

And so when you look at water-soluble cannabinoids, A, the distilled cannabinoids that Trait has developed, actually are odorless, tasteless, and perfectly clear. So they're an easy ingredient to work with and really provide a solid foundation to develop very, very pleasant-tasting beverages or edibles without the need to coat those flavors or mask those flavors with sugar or otherwise.

But also there's evidence to suggest that the onset and bioavailability of water-soluble cannabinoids is much preferential. That you'd feel the effects within, you know, 5 to 10 minutes and in a timeframe consistent with alcohol as well because of the higher bioavailability, because more is getting into your bloodstream without having to be metabolized or in fact removed from your bloodstream by your liver. And you don't need as many cannabinoids to actually deliver the same therapeutic effect to a person.

And so water solubility in my mind really opens up a massive potential for cannabis-based beverages or cannabinoid-based beverages. But in the same token, you know, they open up the potential for different vaping technologies that don't rely on propylene glycol as the accelerant.

You know, it opens up the potential for different pharmaceutical products that'll deliver a much more tailored and precise PK, so the amount of active pharmaceutical ingredient in your blood. So there's a number of opportunities in which water-soluble cannabinoids are going to be relevant. But what piqued my interest about Trait, having been in the cannabis industry, was cannabis beverages and really opening up the potential around them.

Matthew: Okay. So you're attaching the cannabinoids through sugar for solubility, is that right? Can you tell us a little bit about that?

Ronan: Yeah, that's exactly it. So we use a process called glycosylation. Glycosylation is actually one of the most commonly found processes in nature. Many, many organisms use this process to... Detoxify is technically the accurate term, but it essentially means modifying the molecule in the body so your body can process it and ultimately excrete it.

And so glycosylation at its base form is just attaching a sugar molecule to another molecule. And so what our process does is, we can use yeast or other cells, naturally occurring cells, that when they encounter a cannabinoid, attempt to glycosylate it. Like, you know, that's what they're built to do. They attach the sugar molecule to it, and as soon as they attach the sugar molecule, it becomes water-soluble.

In many ways, it's very similar to fermentation, when yeast encounters sugar and they ferment that sugar into alcohol. It's very similar to what we're doing, except we're not fermenting sugar into alcohol. We're fermenting essentially a fat-soluble cannabinoid into a water-soluble cannabinoid.

Matthew: Okay. So it's like, kind of, how a motorcycle has a sidecar attached to it, bolted on where you have the water-soluble sugar, and then you're, kind of, bolting on, kind of, a stowaway to help get the water solubility for the cannabinoid. Is that right?

Ronan: Yeah, in a sense. You're taking on the fat-soluble cannabinoid, you're attaching a sugar molecule to it, and as a result of the water solubility, and I think the chemical reaction happens when you bolt down that sugar molecule, it becomes water-soluble. In fact, you know, this process is so common and naturally-occurring, that's what our bodies do naturally, actually. Your body will naturally bolt down the sidecar to a cannabinoid as it's trying to metabolize the cannabinoid and gets ready to excrete it out. So it's much more comfortable than attaching a sidecar to a cannabinoid in your body, but it's not an inappropriate description of how it works.

Matthew: Okay. And what is Trait Amplification, and why is that concept important to understand?

Ronan: Yeah, so Trait Amplified is a technology that we developed. Actually, it's one of the core technologies that we've developed from which many other technologies have sprung. But it is designed to try and increase yields of cannabinoids in hemp and cannabis plants. Our perspective on the growth of the industry is that for many products, people will not be looking to have dried bud as the end product to consume to vape or smoke, but will rather be looking for, you know, value-added products, whether it's beverages, or edibles, or lozenges, or anything else along those lines.

And so the key ingredient, the key focus, in terms of cultivation, should then be not the number of grams or ounces of bud that a plant can generate, but how many cannabinoids can be generated in it. And so Trait Amplified is a series of strategies that attempt to increase the number of cannabinoids, whether it's THC, or CBD, or any of the minor cannabinoids, increase the amount of yield per plant that cultivators can get from their cultivation efforts. And it's actually been quite successful.

There's a number of different strategies that go into it, but the first ones that we've put into the plant and seen to fruition have increased CBD production by a factor of four. So you're getting four times as much CBD in the plant relative to conventional plants, and three times as much THC. So it's really quite powerful technology in terms of increasing yields, lowering the amount of inputs that need to go into cannabis or hemp cultivation, and by extension also, lowering the environmental footprint that cannabis and hemp cultivation has because you don't have to have as much light or water to generate the same amount of cannabinoids per plant.

So it's quite an amazing technology that Dr. Sayre, our Chief Science Officer has developed, and has great promise for the future of the industry. And coincidently, actually, Trait Distilled, the water-soluble technology is a, kind of, evolution of Trait Amplified because the first strategy Dr. Sayre used to try and increase cannabinoid yields was to detoxify the cannabinoids synthesis process in the plant.

So when the plant is creating cannabinoids, that process is actually, kind of, toxic to the plant which is why you get cannabinoids only in the bud stored in trichome. But if you detoxify that process through glycosylation, you actually open up the plant to being able to grow cannabinoids in every single cell of the plant, not just the bud.

So that's where he started. His efforts increased yield as a result, but we then realized that you can take that process and do it outside of the plant, and do it through a fermentation system. So you could take conventional extracts and just put them into a fermentation system and change the fat-soluble cannabinoids into water-soluble cannabinoids after the fact. Yeah, so Trait Amplified is, going back to the root of your question, is our technology or series of strategies that increase cannabinoid yields in cannabis and hemp.

Matthew: Okay. So you're saying that cannabinoids are actually toxic to the plant itself that's why it's, kind of, not part of the plant, but, kind of, exogenous to it. It dangles off in the flower. But now that you can harvest the desirable cannabinoids you want in the plant itself, you could have, you know, higher density of what you're looking for as your output.

Ronan: Yeah, that's exactly it. I mean, by and large, cannabinoids were developed by the plant as a defense mechanism to, you know, keep it safe. And so you can understand why cannabinoids may not be in high concentrations, great to the plant. And so, if you can find a way to make them safe for the plant, you can grow a lot more of them. This is, kind of, the simple way of looking at it.

Matthew: Okay. And there's a growing interest around minor cannabinoids. Why is that, do you think?

Ronan: Yeah. No, there's a great amount of interest in minor cannabinoids. You know, I think there's a lot of reasons for it, which is there's more and more evidence showing that the minor cannabinoids have different therapeutic opportunities than THC and CBD. For instance, one of the most commonly discussed is CBN, which is one of the more commonly found minor cannabinoids and having potentially great therapeutic impact for people who have sleep problems.

And the challenge with the minor cannabinoids is that they show up in such small quantities, it's hard to do research on them, and it's certainly hard to produce them at enough scale to create products around them. And so a lot of groups have invested money into different technologies to create the minor cannabinoids so they can be scaled, so they can be researched.

And most of these groups, most of the other groups who are doing it are using yeast biosynthesis, which is a potentially very effective way of doing it that involves introducing the genetic framework for creating cannabinoids into things like yeast. But Trait has actually developed a process to create... We believe we can get to about 80% of the minor cannabinoids with a process that doesn't involve yeast biosynthesis at all. It's actually quite a simple process to generate those minor cannabinoids. But, you know, like, anything that's rare, there's always interest in value in something that's rare, and that's why there's so much interest in minor cannabinoids right now.

Matthew: Yeah, this is a point I want to, kind of, go a little deeper into, is, kind of, the difference between biosynthesis and Trait Amplification, what you're doing. Whereas Trait Amplification is where you're, kind of, tweaking the plant to get the most desirable attributes that you want as your output. And biosynthesis is essentially making the cannabinoids in a lab with yeast.

And could you just go over in little more detail why you think what you're doing is different and better just so people get that because I see this biosynthesis, and some people call it cellular farming, is becoming a big theme in the cannabis space, and I just, kind of, want to make sure people understand the contrast.

Ronan: Yeah. So I should clarify. There's actually two different approaches that we have within Trait, generating minor cannabinoids. So one is part of Trait Amplified, that technology, and what that technology essentially does is... Let me take a step back.

Our philosophy has always been that the cannabis and hemp plant is already optimized as much as nature can go to produce the cannabinoids. So to try and take the genetic infrastructure out of the cannabis and hemp plant and implant it into yeast, or algae, or any of the other cellular farming techniques to get those other organisms to produce cannabinoids and minor cannabinoids, it's a challenging process, right? You're essentially having to rebuild the genetic infrastructure of a cannabis plant in another organism when the cannabis and hemp plant has already built that infrastructure.

So our philosophy is instead of trying to rebuild it in another organism, why not focus on trying to optimize the plant to produce CBD, THC, or any of the minor cannabinoids? Whatever the genetic pathways are that are, you know, biosynthesis or the cellular farms are doing and putting into yeast, they already exist in the plant. So instead of rebuilding them, why not tweak them? Why not optimize them and get the plant to do it in the most efficient format? Because nature has invested hundreds of thousands, if not millions of years turning this plant into the best organism on the planet to do this kind of stuff.

Matthew: Right.

Ronan: That's not to say that there aren't, you know, good reasons to explore yeast and algae biosynthesis as well. It just seems inefficient to us to try and get those organisms to do the work that the plant was designed by nature to do. So our efforts are on optimizing what the plant can do.

We have a second strategy for producing minor cannabinoids as well. That, you know, is an entirely different process and just subject because we're still in the process of filing pens around it. I can't provide a whole lot of detail to it. But it's a much simpler process than yeast biosynthesis. And so, just by virtue of it being simpler, it's advantageous in that way.

And secondly, for both Trait Amplified as well as this other strategy, you know, it's... I'm not going to say it's easy by any stretch of the imagination to get yeast biosynthesis to work in any organisms, but the challenges of cellular farming increase as you try and scale it. So it's a lot of work just to get it done on a super small scale, but it's not linear. It's not like, "Okay, we can do it in a small batch, so we can do it in a large batch. Just multiply it by 100 and it works that way."

Many companies have failed trying to scale yeast biosynthesis systems because it's not a straight-line expansion. There's a lot of challenges in scale. And so if you don't have to do that, why would you do that? And that's always been our philosophy and approach to all the technologies that we undertake.

Matthew: When you're trying to increase or amplify a specific attribute of the plant, let's say the CBD factor, are some of the cannabinoids easier to do than others? For example, is CBN easier than CBD or vice versa, or is, kind of, uniform in their difficulty?

Ronan: You know, I would say that it's more difficult as you get down into the minor cannabinoids. And that's just a function of the pathways from which cannabinoids are generated. So virtually, all cannabinoids come from CBGA and then within the plant, the plant will convert that CBGA into THC, and CBD, and other cannabinoids. But then there's, like, sometimes a secondary step and a third step where the THC, the plant then convert that into CBN.

For instance, CBN is a natural result of the degradation of THC. And so the further you go down those pathways, the more challenging it gets just because there's more steps that you have to introduce the genes to, to take the CBGA and to make it into THC, and then take the THC to make it into something else, and then make that other thing into another thing.

So you just see how the complexity increases because it's not always, you know, a single gene that does all the work, you have to start introducing multiple genes. So certainly, it's easier to hit the major cannabinoids in terms of any biosynthesis process. As you get into the minors, it gets progressively more complex.

Matthew: So do you adhere to the idea of the entourage effect then where the minor cannabinoids in the plant work together to, kind of, support, you know, holistic benefit? What are your thoughts around that?

Ronan: Yeah, I mean, I believe in whatever the evidence demonstrates. You know, and so the evidence around the entourage effect is anecdotal right now. But certainly, from my background, I helped start a company called Canadian Cannabis Clinics before joining Trait.

You know, anecdotally, the experience we had with our patients is that people seem to have better results when they were using either cannabis or cannabinoid products that had, like, the full spectrum or full milieu than cannabinoids as opposed to a single molecule.

So that lends credence to the belief that there is something to the entourage effect. But I remain very much open-minded as to whether the evidence supports it or not. But right now, the evidence that I'm familiar with or are aware of would suggest that there is some merit to the entourage effect improving the therapeutic efficacy of cannabis.

Matthew: And how big of an opportunity is licensing your IP going to be do you think?

Ronan: I think it's going to be massive. You know, the technologies that Trait have built, like I said before, are built around what I think are the biggest opportunities in the industry, and I think they are truly like the platform technologies that the future of the industry is going to be built on. You know, our water-soluble technology is certainly the most efficient and easiest to scale in terms of consistent results and deliverables. And because of the efficacy around, and the better bioavailability and onset of water-soluble technologies, you know, I think we'll be the only viable player in that respect. Other people are working on it certainly, but I genuinely believe our technologies are far superior in terms of the outputs, in terms of scalability.

Same with Trait Amplified, which is...you know, it's all cannabis producers and hemp producers are trying to lower their costs. And the orders of magnitude improvements that our technology has still, you know, not fully implemented yet because it takes...you take a phased approach to introduce and stack new technologies on top of each other. But, you know, we've conservatively estimated that we'd increase yields by three to four times, conventional plants.

And just by introducing one of our strategies, let alone the numerous other strategies in the pipeline, we've already achieved that. So the increases in yields that we will be able to generate are quite substantial. And as far as I'm aware, no one is doing that work at the level we're doing it at, with a team that's behind it, and achieving the same results. So I also believe that Trait Amplified is going to become a platform technology that almost all producers will end up using because those who are are going to have significantly improved cost advantages relative to everybody else.

Matthew: And where are you in the capital-raising process right now?

Ronan: We are not actively raising capital right now. We finished financing fairly recently. So we have more than sufficient cash to execute on our research and scaling plan for the next 12 to 18 months. And then, you know, as we get closer to that timeframe or if any opportunities come up, we may revisit that conversation. But as it stands right now, Trait is well-capitalized to execute on its vision.

Matthew: Okay. And where do you see biotech and cannabis going in the next five years? Where is this arc going to lead us?

Ronan: Yeah, I mean my instinct says it follows a trajectory very similar to what you've seen with the other major crops: corn, soy, rice, which is there's going to be heavy investment in terms of new technologies to create more robust, healthier, higher-yielding plants, because it's going to bring the cost of production down and it's going to enable innovation. You know, it's going to establish more certainty of supply chain, more predictable products.

You know, one of the challenges that still exist is growers right now may produce one strain in one lot using the exact same genetics, because nature is sometimes fickle, you'll get different cannabinoid profiles in the next lot. You're going to notice the exact same genetics.

So I think all the effort to produce consistent, robust, healthy high-yielding plants are going to be the direction that cannabis biotech and the cannabis industry is going to head in. And I think that's, you know, particularly supported by where I think the product demand is going to be, which is going to be in the value-added products of beverages, vapes, edibles, all that kind of stuff, pharmaceuticals as opposed to the flowers. So those groups that can produce consistently and at low cost are going to be the most successful. And so, you know, the technology will lead that direction over the next few years.

Matthew: Okay. Ronan, I'd like to ask a few personal development questions to help listeners get a better sense of who you are. With that, is there a book that's had a big impact on your life or your way of thinking that you'd like to share?

Ronan: Yeah. My favorite author, by a long shot, is an author by the name of Tom Robbins. People often confuse him with Tony Robbins who's the motivational speaker. Not Tony Robbins, Tom Robbins. Tom Robbins...

Matthew: Yes, "Still Life with Woodpecker," right?

Ronan: "Still Life with Woodpecker."Actually, that's the exact book. And, there's been a couple of instances where I've been reading that book and the philosophy underlying that book is so life-affirming. It challenges you to get out there and lead the life that you live or you want to live. And I remember at one point, reading that book, lying in bed, and reading a particular passage about how one person can be more real than any other person. And I had to sit up in bed and, you know, really absorb that passage. And based on that, I took a couple of bold moves and changed the direction of my life, just based on reading one paragraph in a book.

Matthew: Wow.

Ronan: And so, "Still Life with Woodpecker," and his book, "Jitterbug Perfume," are my two favorite books. And the philosophy that underpins both of those books is similar. It's all about getting out there, living your life, taking chances, you know, not obeying convention, being true to yourself. And I think everybody would benefit from reading those books because they're A, beautifully written, but B, by trying to absorb that philosophy, I think you can lead a much better life.

Matthew: What do you think is the most interesting thing going on in your field apart from what you're doing exactly?

Ronan: This is a bit of a cop-out answer, but I think what we're doing is the most interesting work. And I guess there's one other answer I'll give, which is not as much of a cop-out, which is, there's a number of groups really, really working hard on formulations, and studying the minor cannabinoids, and seeing the health impacts that they have.

You know, there's been a lot of anecdotal evidence about how cannabinoids can treat, or stop the development of tumors, or kill cancer cells. And certainly, there's lots of in vitro evidence to support that. But there are some groups, some based in Israel that are taking that to the next level, you know, and creating formulations, and understanding the biomechanics of how and why they are effective at treating different conditions. And I think that's super exciting.

You know, it's one of those things that when you learn about the endocannabinoid system in your body, that you realize that, you know, we're, kind of, designed to work with these molecules, and it's quite fascinating. And the more work we do on all the different cannabinoids and the impact they have on our bodies and our lives, it's just fascinating to me.

Matthew: Here's a Peter Thiel question for you. What is one thought that you have that most people would disagree with you on?

Ronan: I am contrarian by nature, and so I'm always advocating being contrarian. I think the best business advice that I've ever learned was, "When everybody is running in one direction, you should be running in the exact opposite direction." And a lot of people disagree with that. A lot of people think it's safer to go with the status quo, to not ruffle feathers, to not, you know, create ripples. And I advocate to anybody, like, "Don't do that. Create ripples. Create noise." Don't create noise for the sake of creating noise. Create noise, you know, because it's true to who you are and what you believe, and don't let anyone tell you otherwise. And so, you know, get off the well-traveled road. Get on the road less traveled by because I think that's where you'll find fulfillment, satisfaction, happiness, challenge, opportunity.

And, yeah, you know, I tell people, especially if people come to me looking for advice about how to crack into a new industry or a new job, I'm like, "The most important thing as always is to be memorable. It's not to be smart. It's not to be witty. It's to be memorable." And I think a lot of people would agree with that but, you know, because logically it makes a ton of sense, but I think very few people actually live by that principle, and it's one I've always tried to live by.

Matthew: Great answers, Ronan, thank you.

Ronan: Thank you, my pleasure.

Matthew: As we close, can you let listeners know how they can find Trait Bio online and connect?

Ronan: Yeah. The best way to reach us is to visit our website, which is www.traitbio, T-R-A-I-T-B-I-O.com. You can find lots of information about our different technologies and our team there. And if you go there today, you'll see our most recent announcement, which is, we just announced the existence of a strategic advisory board. You know, like I was saying earlier, I think our technologies, particularly the water-soluble, have a lot of impact for future product developments. And the strategic advisory board that we just advised, I think, is reflective of that.

We have a VP from Coca-Cola joining our strategic advisory board. We have the President of Bacardi, the beverage alcohol company. And we also have a former Senior Executive from Wrigley Mars joining our advisory board. And I think all of them are excited to be working with us because they see the potential that these technologies have to develop amazing new products. So that's my final little plug for today.

Matthew: Great. We get a lot of irons in the fire. Good luck to everything that you're doing. And please be sure to circle back and let us know how things are evolving.

Ronan: I certainly will. Thank you so much for the time today, Matt.

Matthew: Thank you.

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Final disclosure to see if you're still paying attention: this little whistle jingle you're listening to will get stuck in your head for the rest of the day. Thanks for listening and look for another CannaInsider episode soon. Take care. Bye-bye.

Ep 276 – New Science Reveals Psilocybin Mushrooms Boast Incredible Benefits

max montrose trichome institute

Could mushrooms be the next cannabis? Here to answer this and provide us some key insights into the fascinating world of psilocybin is Max Montrose, President of Trichome Institute.

https://www.cannainsider.com/go-trichome-classes

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DISCLAIMER: DO NOT USE ANY DRUGS OR SUBSTANCES WITHOUT CONSULTING A MEDICAL PROFESSIONAL. THIS IS FOR INFORMATIONAL PURPOSES ONLY.

Key Takeaways:

  • Max’s background in cannabis and how he came to start Trichome Institute
  • An inside look at Trichome Institute and its mission to set the highest standard for science, education, and certification in cannabis 
  • Counterfeit cannabis strains and why the products you’re buying may not be what you think they are
  • Why Max believes we need to change our terminology for sativa and indica
  • Factors that determine a strain’s potency and why THC isn’t everything
  • Trichomes and Max’s recent discovery of a seventh cannabis trichome
  • Terpenes and the importance of smell in deducing good terpene chemistry
  • What the term “OG” actually means
  • The Trichome Institute’s new Interpening book and what sets it apart from other books on cannabis
  • A deep dive into psilocybin mushrooms and their life-changing benefits
  • How the decriminalization of psychedelic mushrooms is gaining traction and what that could mean for you
  • Common misinformation surrounding psilocybin
  • Max’s advice on how to achieve an optimal mushroom experience
  • Where Max sees psychedelic mushrooms heading over the next 5-10 years
Click Here to Read Full Transcript

Matthew: Hi. I'm Matthew Kind. Every Monday look for a fresh new episode where I'll take you behind the scenes and interview the insiders that are shaping the rapidly evolving cannabis industry. Learn more at cannainsider.com. That's cannainsider.com. Now here's your program.

Hey, CannaInsiders. Here's three things you're going to love about today's interview. One, killer why and how the cannabis you are buying at your local dispensary may not be the strain you think it is. Two, what the term OG means. Hint, it's not what you think. Three, how the decriminalization of psychedelic mushrooms is gaining speed and what that means for you. Lastly, the information we are providing about cannabis and psychedelics in general is for informational purposes only. Please talk to your doctor before taking any drugs. Now here's your program.

Just as soon as we feel like we have reached a new stage in our understanding of the cannabis plant, more key insights emerge to help us grasp how this plant can change lives and help heal the planet. Here to help us open our minds and dispel myths about cannabis is Max Montrose, founder of Trichome Institute. Max, welcome back to CannaInsider.

Max: Thank you so much for having me back on the show. Happy to be here.

Matthew: Give us a sense of geography. Where are you in the world today?

Max: I am in good old Denver, Colorado, in my happy place, which is my greenhouse in the backyard.

Matthew: Great. For new listeners, can you give a high level overview of what the Trichome Institute is?

Max: Yeah. So for all those new listeners out there, we are an education company in the cannabis space that has a very different approach to teaching people about cannabis, the plant, what it actually is, why it's not Indica or Sativa, why THC doesn't equate to potency, why screen names aren't reliable. And how we teach those things are actually in very interesting ways. We take our approach more from the structure of how people teach wine experts to be wine sommeliers. But we also write other textbooks on cannabis, industry textbooks such as the Responsible Vendor Program, which is we're certified in the State of Colorado by health divisions, marijuana enforcement divisions, and we put together other curriculums. We run cannabis cups. We do consulting. We do a lot of different things in the cannabis space. But I think the most important thing to note is how and why we do things so differently.

Matthew: How about can you share a little bit about your background and journey and how you got into this cannabis space and how you started Trichome Institute? It seems like you're like the perfect age, place and, personality for this cultural zeitgeist. So I want to understand how you stepped into it.

Max: Yeah. I think the way you put it was perfect. And this, you know, this comes up from time to time how kind of perfect it is. My age, my passion, where I am. And, in all honesty, it really is kind of a perfect recipe. I feel like I am on this planet, at this time, this type of person in the family that I was placed in to do this work. And so I grew up with cannabis, when it was against the law on the black market, dreaming of some time when it would be legal in the industry. And the plant actually helped me get off of a variety of different pharmaceuticals when I was quite young, the plant started teaching me things, and how to observe it and work with it in different ways.

And I basically fell in love. I became enamored and I also became upset that it was against the law, and people would, you know, get in trouble for this thing. So yeah, I became an activist, you know, when the marijuana movement was literally happening in my own backyard. And I essentially grew up with the cannabis industry. When I was in high school, we were just beginning to fight for it and all throughout college. And by the time I got out of college, I started working in the industry. And the industry started slowly becoming more and more professional as I started doing different jobs in the business, as well as becoming just also frustrated with people's information based on this plant and patients' access to getting the stuff that they need. And that's really kind of what drove the need for education and legitimate education specifically. And so that's pretty much where the Trichome Institute came from.

Matthew: I had some cognitive dissonance when, you know, the first time I smoked marijuana, you know, as a young teen, and kind of waking up to the fact that it was so much different than the society around me interpreted. And then kind of from the outside world, I'm a criminal. But I know that there's something special here. And how did you kind of reconcile those two clashing thoughts?

Max: Well, I'll tell you a funny story that I don't tell most people. The first few times I was smoking cannabis, when I was just so blown away by how incredible it was that I could have so much control over my own self-alchemy. And placed myself, my mind, my body, my spirit into different places of understanding and exploration and how just unbelievably interesting that is. Just pure fascination. And I just wanted to try it all the time. And I was really young. And I was so scared of getting caught by my parents or, you know, the law because I know how illegal it was.

I actually used to dress up any camouflage and go down to the creek and like hide in nature and smoke weed in a ghillie suit. I was so scared to get caught. And people who know me, I'm like the weed guy like around the world, you know? And so it's funny like because I've got every single psychedelic drug you could ever imagine tattooed to my left leg. And people just know I'm not afraid whatsoever to tell the whole world how much I love this stuff. But boy, when I was a young teenager before I kind of grew into who I am now, I mean, I was really scared. Yeah.

Matthew: Yeah. That's funny. I love the camouflage. Oh, man, I wish we have a picture of that.

Max: Yeah. Little redheaded ginger Max hiding in the bushes, smoking weed.

Matthew: Oh, my God. And, Max, you talk about counterfeit strains. And I think it's important for people to understand what that means if this is their first time hearing you. Can you talk a little bit about that? And how if you go into, say, four different dispensaries in Denver or any city and buy let's say Blue Dream just because that's easy. Is that really Blue Dream? And how do you think about it differently than someone else in the space?

Max: Well, Blue Dream is my favorite example. So much so that when we discuss what the strain name dilemma is, where it comes from, what it means, and why it's problematic, we use Blue Dream as the example in the new interpening book, our 130-page hardcover. It's in our new course online. But it's also in like little cool videos on our Instagram and also YouTube. So like if you were to YouTube Colorado's most counterfeit strain, it's a leaf viral video that they did of me actually going around Denver buying Blue Dream, bringing it back to the office. And what we were doing is analyzing its inflorescence. And for people who don't know what that means, it's basically the elements of the flower structure.

And so we were essentially just putting them next to each other and demonstrating how the bracketing structure, the style and stigma structure, the length, the color, the robustness, the smell, the thickness between the bracketing structure was just fundamentally different between the different varietals of "Blue Dream" that I picked up just that hour. And two of them actually looked like, smelled like, felt like, what you would consider Blue Dream, if you had the ability to know that varietals typicity. And typicity is a new term for the cannabis industry. It comes from the world wine sommelier.

But, you know, a lot of industry OGs, if they think about the flavor, Durban Poison, or Ghost Strain Haze, or Jack Herer, these really classic strains that are totally real and true, they know those tastes and those flavors. They can almost taste them just by thinking about them. But these flavors are so unique, that there literally is nothing on the planet similar to them. You cannot describe to someone what Durban Poison smells like. It's kind of like explaining to a blind person a specific color pattern. It doesn't work.

And so what typicity is, is having that intimate relationship with that specific thing that you have to know from knowing it personally. So I can show you what Blue Dream or Durban Poison is in our expert level interpreting courses and classes to associate your senses with its typicty so you have that understanding. But how much of the people who smoke weed do that? And how much of the industry, right? Like the majority of the industry is kind of like Coors and Budweiser. You walk into a dispensary, they call it Blue Dream. You buy some weed and I guess it makes you high and you're happy. But for the people who care, is it Blue Dream? And, you know, it most likely isn't.

And then that's where we get into trouble because the majority of people who purchase cannabis buy cannabis based on two things, the strain name and its THC percentage. And those two things tell you the very least about what it is that you're engaging. And so I would say our approach is pretty different and serious by saying...we tell people to give up on screen names because they don't matter. And what does matter is your ability to know what you are engaging, the quality of it and how it will make you feel. On a big spectrum of psycho pharmacy, not one or the other because Indica and Sativa are something other people need to also better understand.

But we also do teach about strains that do deserve names. And so like in Northern California, like in the world of wine, there are some really serious, sophisticated OGs who deserve the utmost respect. And not just them but the specific strains that they invented, have been working on, perfected, and then continue to grow in the same way, in the same area, the same appellation within the same terroir. And when you do have that type of consistency, that's what's considered landrace, which is funny because that's the opposite of what the cannabis industry thinks the word landrace means. They think it's some wild plant out like in nature brought back. It's the opposite. And so those true land races with those true heritages that have a story to tell and a unique experience to experience deserve to be called what they're called. That's why we need truth and labeling laws. And that's why like the cannabis industry, you know, is slowly moving in that direction. But some of this stuff can get quite complex.

Matthew: Yeah. Now, you're proposing new terms replace Indica and Sativa. Can you talk about that and why it's important?

Max: Yeah, absolutely. It's super important because Indica and Sativa aren't correct. Now, from a, like, let's just all chill out perspective, it is helpful to have, you know, a communication, right? Like that's helpful. And so if it helps people to communicate that when you say Sativa you mean a stimulant. And when you say Indica you mean a sedative. Fantastic, right? Like I don't want to stop quality communication, right? But then you judge the Cannabis Cup. And so I get paid to fly to Oregon with my team of cannabis experts. And we literally are given 200 of the most gorgeous genetics, some of them, some of them we're actually wondering why it's in a Cannabis Cup.

And you start digging through the Sativa entries and these are the most sedative flowers, you've seen some of them, a handful of them. And vice versa. You dig through the Indica category and my whole team is looking around at each other. We're just like, "This is the sexiest stimulating flower of ganja ever. I mean, we're going to give it a great score on a quality perspective. But why is it in the Indica category?" And if that happens at the level of cannabis competitions, then you know that this is happening more often at the level of the dispensary. And so even if you're communicating terms like Indica and Sativa meaning stimulating and sedative, who's to say whatever nuggets in the jar is what you're trying to ask for when the terminology you're using is incorrect to begin with?

Matthew: Right. Oh, my God.

Max: Holy smokes. Okay. So...

Matthew: Can you describe the last one that actually won and what that was like? I'm just curious.

Max: Well, actually the best flower that won was 14% THC and was just the most gorgeous thing in the world. I mean, we rarely get 98 and 99 on our point scale and this thing was like tipping the radar in ways we've never seen before. And we announced to the audience that the winning flower was not the 32% THC, it was the 14%. And a lot of people were really shocked by that. But it's like I hate to break it to you. THC is not quality. THC is a molecule and it does something. And the rest of the planet and how it's composed and how it's grown and the smoothness of it and the cleanliness of it and the rest of its, you know, composition, chemical composition is what makes it it outside of just it's THC.

THC is not quality. It's a part of the plant. And then the funny thing is, and we crush this in our split busters episode with like cool graphics and everything to help people understand. But we just teach people why, you know, the 14% flower could literally get you two, maybe even three times more intoxicated than the flower at 32% THC. And it's because the flower with the really high amount of THC is super low in the rest of its other psychoactive chemistry. Dozens and dozens of other cannabinoids and terpenes due to its health and its quality. And so, yeah, people kind of need reeducation on what good cannabis is.

Matthew: Right. It's like saying, "Hey, the only measure of a good cake is it has a ton of sweetness." And, you know, that there's more to a cake than that.

Max: I have more analogies in my back pocket.

Matthew: Oh, good. Throw them out there. I know you got a switchblade full of analogies. Let's do it.

Max: Well, so one of our analogies when we talk about like THC isolate is how excited a lot of people and by people I really mean stoners are to have the highest THC they can get. Like this has been a mission in our culture for probably the past decade. Like can we achieve 99.9% THC? And we have. We've done it and it's isolate and it looks cool. It is kind of cool. And then what's really interesting is even freebase 99% THC, right, if you dab it that is still not half as strong as taking one like puff of flower of 20% THC in a bowl. And it's really fascinating.

And so there's a few things to this. One the analogy is, which would you prefer? A spoonful of sugar or a slab of chocolate cake?And because like sugar is crystalline and if you get THC to a crystalline state, there you go. Congratulations. And it on its own kind of sucks. But when you kind of mix it together and you put it together in the most perfect composition, you actually create this thing that is more desirable and in a lot of different ways.

Matthew: That's interesting. Now you mentioned that you discovered a seventh type of trichome in cannabis. First, can you explain what a trichome is for new listeners but also what you found there?

Max: Yeah. So trichomes are super cool.

Matthew: You named your company after the trichome.

Max: I did. Well, yeah, Trichome Institute. And it's more than they're just super cool. They're actually super important. The word trichome comes from the old word trichoma which means hairs. That's old Greek. And if you look at a sunflower plant or a tomato plant and then the plant looks a little hairy, it is their trichomes that is that composition that you're looking at. And so on the cannabis plant, cannabis is cool because it grows a variety of different types of trichomes. It grows two types of trichomes that are considered non-glandular, which means they don't grow a head full of fatty lipids that can and does produce chemistry.

And so those trichomes are cystolithic trichomes and unicellular trichomes, and my analogy for that is those are the little spikes above the buildings of every Starbucks that prevent pigeons from landing so that they don't, you know, take a crap on your head. Literally same point on plants. There's no difference. So the plant just grows it's like little spiky force field to prevent bugs and other things from getting near it. Outside of that, the glandular trichomes comes that the cannabis plant does produce, you know, two types of bulbous trichomes, sessile trichomes and of course everyone's favorite, the capitate-stalked trichome. The big, bad, beautiful, gorgeous mushroom looking gland.

And that gland is what photosynthesizes cannabinoids, terpenes, and flavonoids. The whole spectrum of it. And it does this based on two things. The first is the plant's blueprint, the DNA, and the genetic code that it's been gifted to produce the chemistry composition that it does. Kind of like our own genetics. And the second is its environment. And it's the same thing as us again, right? Like we are a product of our genes and our environment and so is cannabis. And so the plants can evolve slightly depending on where they are and how they're taken care of.

But when it comes to the seventh trichome, geez, I can rant. I'm sorry about that. Holy smokes. Are we even talking about the seventh trichome anymore? Okay. So yeah, so the seventh trichome. So if you're really hip to your cannabis science, you most likely have a copy of the "North American Cannabis Pharmacopoeia," which I believe is a 2012 publication, and it has been reupdated. But in this publication, they really break down the cannabis plant, cannabis inflorescence in a really great way. And so this is the scientific community, essentially doing what I did with the interpening book, except our pictures are 1,000 times more gorgeous. Their pictures are like kind of blurry in a laboratory and ours are like National Geographic quality. We're pretty proud.

But they just show you the different trichomes. They show you what they look like and they label what they are. And we have a photo in our book of the seventh trichome that we've never seen published in Science anywhere before. And it is a type of capitate-stalked trichome. And what's really interesting about it is instead of having a head like a mushroom, the head is more like a teardrop. And the tip of the drop of the tear is actually pointed outward, if you can imagine that. And what's really interesting about this type of trichome is this type of icon is the most dominant trichome type of tobacco.

I grow six varieties of tobacco, really interesting vines from deep parts of the jungle, native tobacco from the U.S., Caribbean tobaccos. I love tobacco. It's my companion plant with cannabis. And tobacco is covered in trichomes. And the types of trichomes that you see on tobacco are this type of trichome that we see on cannabis every blue moon. We saw it twice on a Cannabis Cup. We talked about six months ago, maybe a year ago now. Geez, yeah. And we do have one photo of it in our book, but we don't know much about it.

Matthew: Is that why in some cultures you see people smoking cannabis with tobacco together? Like I've seen in South America and some places in Europe where it's a joint consists of both tobacco and cannabis flower.

Max: Yeah, there's a few reasons for what's called a spliff. And, you know, that's the difference between a joint and a spliff is the tobacco combination. When I was...

Matthew: I never understood that. I've always wondered why that is?

Max: Yeah. So a spliff and that term is European. And the other way to consider a spliff is by calling it a European.

Matthew: Okay. You know, it's funny, I try to talk to people in other countries and I've asked people like, "Why are you putting tobacco in here?" And typically, the answer I get is that they don't even know. It's like they've been doing for so long that it's like why do you have like a line with your coke? And it's just like, "Well, I guess I like the flavor. But I'm not even really stopping to think about it much anymore because I've been doing it for so long." Like I can't get an answer here. It's always like, "I don't know."

Max: Yeah, yeah. And in Europe, that's just kind of how they do it. It's actually just kind of part of the culture, whether it's flower or not. That's just kind of what they do. It's just kind of their thing. But here's something interesting about spliff smokers, once you've got a spliff smoker on your hands, it's kind of hard to get them back to being simply cannabis smokers. So lots of people who do combine nicotine with their cannabis, it's such a different experience that actually when you do go back to smoking a joint, I could actually see why those people in Europe just never do. It's like it just doesn't almost make sense. Like if that makes sense.

Matthew: Yeah. It's kind of like once you have cream in your coffee. Like you're not gonna go back to black coffee. It's like the habit is formed.

Max: Yeah, correct. Correct.

Matthew: Yeah. Now, is there a smell determines leaving the plant? And why should we care about that?

Max: Well, yes, I mean, the terpenes in and of themselves are the smell of the cannabis plant. And these smells are in a state of evaporation. And if they weren't literally wafting themselves continuously in a chain of isomers the way that they are and do, you wouldn't be able to smell that. Like two feet from the plant. And it's kind of funny. Like it's kind of like a no duh sort of thing. But sometimes when you just give people that imagination for two seconds. They kind of get it a little more.

Matthew: That makes sense.

Max: Yeah, like if you could see them and, you know, my analogy for terpenes is they're the little beer bubbles on the size of your glass of your beer. And so if you pour a beer that is more clear than foggy and close to the bottom of the glass, like you can see that pinhead that's almost invisible to see. Then from that invisible, tiny point, it makes absolutely no sense how it can stem thousands and thousands and thousands of large gas bubbles from that point so much so that it creates the head of the beer when all of those little bubbles on the side of the glass together create the head. And the head of the beer is the total smell of the cannabis plant. It is the bouquet of the totality of all of the dozens and dozens or even hundreds and dozens of terpenes types in a constant wafting state from the plant.

So when you smell Durban Poison, you are not smelling the 6 or 12 or even 40 terpenes that your local cannabis laboratory, gas chromatography for the terpenes types. They're not telling you the other potentially hundred other terpenes in that arrangement that is making that specific smell, Durban Poison, that specific smell. And that's also why when you go to a lot of the some types of terpene companies who sell terpenes with strain names on them, when you smell the terpenes, and you're just like, "This doesn't even smell like weed." The reason why is there only combining the 6 or 12 of the types of terpenes let's say from that Durban Poison example. But they're not combining the other 150 that actually make that smell.

And so are they important? Yeah, they're important because not only can you smell them, they have a psycho pharmacy. And they're dictating the difference between your stimulating and your sedative experience. And so what happens if you have a cannabis industry that has a situation where it grows so much product and it takes so long to move it that, you know, 100 pounds later from a specific harvest by the time you're on your last pound in the dispensary, that flower could be sitting for six months or longer. And potentially in ways that might not have kept the cure in the best way.

And so if you approach, not even a dispensary. There's black market weed, too. We're just talking about cannabis in general. If you approach cannabis that you have a difficult time smelling, your face is doing chemistry. Your face is detecting the lack of terpene types that are there. And thus you can do something really easy. There is a lack of chemistry. What kind of chemistry? Stimulating and sedative chemistry. So what do you left with? Your run of the mill cannabinoids and that's kind of like a vape pen without terpenes in it. Like you can get high but you just might not go up or down. You'll get high moving forward, if that makes sense.

Matthew: Yeah. Now, we hear the term OG thrown around a lot in the cannabis community but people misunderstand it. Can you tell us what that means?

Max: Yeah, absolutely. So there's going to be listeners who are definitely going to disagree with this so listen up listeners. And I say that because it's funny. What's funny is even words like OG, people are so passionate about. Like the amount of passion people have for this plant, this culture and this industry. It's really intense. And so, to me, it's kind of funny, like how serious people get sometimes about things like the word OG. And so what a lot of people think it means is ocean ground. And what drives me crazy is I hadn't found one person who believes it means ocean ground and has had an ability to explain that to me in a way that makes sense.

And so if you just meditate on it for two seconds, it just doesn't make sense. It's because it's like because nobody grows weed at the ocean. Nobody grows weed at the beach. And, yes, the Pacific Northwest does grow the best weed in the world, from California to Oregon to Washington to BC. Like it's true. But when they're 100 or 200 miles inland, just because their geography on a map like comes near an ocean, does that mean it's ocean ground? It's just like it's just ridiculous. There has to be meaning and context of vocabulary. Which is why our new terms for Indica and Sativa are so cool. If you want to talk about that still, we can do that.

But so just to get this over with, OG does mean original gangster. And you have to pay respects to the original gangsters. Who are the original gangsters? All of the growers in the Emerald Triangle that literally risked their entire lives, their land, and their families to give this country the cannabis that's had for decades during its prohibition. And who respects them as gangsters? Gangsters themselves. So when gangsters are rapping in South Central LA about the really good gooey, sticky chronic without the seeds and the stems that's coming from up north, those dudes are paying tribute to the other gangsters because what they do is super gangster. They got helicopters coming after him for Christ sakes. Don't say it's not gangster.

And so people were also looking for original types of Kush in the '90s because when a lot of the Kush varietals were coming out of the Emerald Triangle, people wanted to know if it was the real kind, if it was the original, the OG Kush. Is this the OG chronic? And so OG comes from that culture and it comes from that place. And it comes from gang culture. And that's totally cool.

Matthew: Now, Max, let's talk...we talked a little bit about the pictures and your book being National Geographic style. But if we had your book out in front of us and its 130 pages, I believe, hardcover, and we were just a pop up a random page, what kind of information do you think would be a juicy little tidbit that people could learn about?

Max: Oh, I'm so glad you asked. I mean, here, instead of a tidbit, here's the whole kit and caboodle. All right? A lot of cannabis books are the same. A lot of them are the same. If you see hash books, they're all the same. Besides that the ones that have personal stories to them, there hasn't been a lot of newness to cannabis in a really long time. And what's really cool about my book, our book, what the Trichome Institute put together, because, oh, my God, I could not have done this by myself. Especially, Chef Brandon Allen, he definitely made this book what it is, 100%.

The whole book is brand new. It's the book that it shows you the new way of cannabis. I don't know of another cannabis book out there currently that educates people on what cannabis Appalachians are, or [inaudible 00:33:55] or typicity or how and why they're not Indica and Sativa what they should be based on science. Most people think the word marijuana is really racist. Our book covers why the word marijuana isn't and why it's super beautiful and why you should use that term. We also have a really cool YouTube on that, by the way, too, with a professor that's like a half hour long. It will blow your mind. It's super awesome.

But, you know, the book is the ability to say, you know, you don't have to...no, from here on out, if you understand interpening methodology for the rest of your life, no matter what situation you're in, whenever you're approaching cannabis, whether you're growing it, buying it, selling it, whatever, talking about it, your ability to understand it from an actual perspective with real words and terms and hold that conversation, but even more so dissect your flower for its quality and for its psychotropic direction, regardless of its lab test and what it's called, is the ultimate power in your own cannabis everything.

So if you're a consumer and you're consuming cannabis for specific reasons, like I want to smoke one type of cannabis to go to bed, another to do my work, but a different kind when I go to this concert. Strain names and lab tests aren't going to help you but interpening will. And so for a book to be, you know, over 100 pages of new cannabis information, we're super proud to offer the industry a way to look at this incredible plant in a way that we believe it deserves. It's real. This is science. This is no more black market culture. This is no more stoner culture. This is not Indica and Sativa anymore. If you want to actually know cannabis at an expert level, this book in our course interpening will most definitely get you there.

Matthew: Okay. Now, Max, we're kind of in an interesting parallel with cannabis with mushrooms. Just for people that know they may have heard some information on the news like mushrooms, Denver, what's the status of mushrooms and their legality in Denver where you live?

Max: So we're talking about magic mushrooms?

Matthew: Yeah, we're talking about psilocybin, right? That's what we're talking about.

Max: Yeah, yeah, psilocybin, magic mushrooms. The current legal status, where I'm standing right now they are decriminalized. And so what that doesn't mean is it doesn't mean they're legal. And it doesn't mean it's medical. And a lot of people kind of get tripped up on that. But what's really fascinating that I think the thing that people should pay attention to is the fact that magic mushrooms are a schedule 1 drug the way cannabis is today. And schedule 1 drugs are defined based on three things only. It is a drug substance that has the highest potential to kill you. It has the highest potential of addiction and it has absolutely zero medical benefit.

Matthew: That's so harsh.

Max: That is the definition of a schedule 1 drug. And what's really fun is I'm unaware of a schedule 1 drug where all of those things that it's defined by should most likely place every drug in that category in probably category schedule 3. And what's really interesting about category schedule 3 is that's where the United States government has chosen to place its version of medical marijuana, which has been legal and on the market longer than I've been alive. So the U.S. government knows the cannabis plant produces this molecule called THC. And they know it's medically beneficial. That's why they turned it into a pharmaceutical called Marinol which was made available on the marketplace in 1985.

Marinol because it is a medicine and it's so non-dangerous or addictive, it's in schedule 3. But our version of cannabis, the medical marijuana industry itself that serves the actual holistic plant, it's in the same category as mushrooms. It provides no medical benefit. And so it's really important to understand this kind of stuff because these are the reasons why we have a multibillion dollar federally illegal industry that's legal that's also illegal because it's legal, right? But these are the nuances that people have to understand so that they can help us navigate this stuff. So when I lecture on psychedelics, I teach people that the path to, you know, drug legalization, ending the war on drugs is it's a recipe. And follow the recipe. And the recipe is the same recipe the State of Colorado did with cannabis.

Our approach to decriminalizing it, then medicalizing it, and then legalizing it is boiling the frog. And the frog that we are boiling are essentially soccer moms and legislators. So if you can get soccer moms and legislators to take a big deep breath and know that mushrooms have a great medical benefit, Johns Hopkins University has been proving how they help people overcome addiction, depression, anxiety, and their greatest medical benefit with highest amount of evidence so far is helping terminally ill patients get over their fear of death, which is really, really important. So imagine, you know, you're going to die. Like this is your last year on Earth, Matt, say goodbye to all your friends and the smell of grass in the morning because you're done. And it's terrifying.

And if you had one substance that you could take and have peace with yourself because you took it and it gave you that peace, how could you take that away from someone who needs that? So we need medical mushrooms and we should have them. And there should be a system that takes care of this situation in a really serious and logical way. And so that's what's happening in Denver right now. And let's not forget Oakland, California as well. And Oakland did more than decriminalized mushrooms. They decriminalized entheogens. And entheogen is a sacred plant medicine. Peyote, ayahuasca, San Pedro, cannabis, [inaudible [00:41:10]. All of them. And so, yeah, this is a big deal, man. This is a really, really big deal.

Matthew: Now, if you were to jump on a subway with a friend and he only had two stops to tell that friend what you find most compelling about mushrooms right now and that limited time, what would you tell them? What would you share?

Max: I would tell them that if you take mushrooms the right way, set setting and skillset. Not a concert or your mom's basement. If you do mushrooms properly, they can change your life. They can put you in its place, in your place in a perspective that is positive and conscious in terms of personal growth. And I think a lot of the world needs that right now including me. It's the same thing as PTSD and what they're doing with MDMA. Same group out of Johns Hopkins maps. Yeah. And also, MDMA, schedule 1, even though it's curing people's PTSD, not curing, treating PTSD. So, yeah, I think this is important stuff to talk about.

Matthew: Well, when I talked to...some people are really on board with that they want to try mushrooms, but you said, you know, set setting and so forth. I am nervous about having a bad trip that seems like I would be out of control. And that's where the fear really comes from. I've been on the edge of having a bad trip before. But like when I just accept what's happening versus try to control it, that's when the bad trip just seems to go away. And it kind of goes back into a good place as long as you're in a fun...not fun, but just kind of a chill environment that's not gonna present too many negative surprises. But can you just kind of talk about how you would answer that question like, "Hey, I'm afraid of having a bad trip? What do you say when people say that?

Max: I'll say good, you should be afraid. You damn right, you should be afraid because if you're not, you're crazy. And it's because if you...you know, first of all, that fear of the unknown is you being your most human. It's a gift to your species to keep you alive. And so use that fear and that amount of caution to ensure that you don't do them wrong, that you do do them right. Be afraid until you're no longer afraid. Because you've done enough homework, you've done enough research. And maybe you've even set yourself up with a trip sitter.

Where I live in Colorado, there are actual trip sitters that you can hire. And these aren't just hippies and T-shirts like tie-dyed T-shirts, right? These are people who have gone to school for psychotherapy, typically at Naropa. And they're highly experienced with these substances. They've done them many times themselves and they know how to help you push through really difficult situations. And they're there for you. Like you're supposed to cry your brains out and have a breakthrough and it gets uncomfortable and it doesn't look pretty. It's not really normal in our society. It's perfectly normal in other cultures all around the world.

And so, you know, if you don't have access to a professional trip sitter, if you have access to mushrooms, you know, don't be afraid to ask a very legitimate, reasonable person who would be a good trip sitter to be there for you. And then also just know that there's a ton of misinformation about mushrooms as there is cannabis. And one of the things that's really frustrating is one of the largest information sources on drugs like mushrooms is Arrowhead. And if you go there and say, "Hey, how much is a dose?" They will say an eight. And that is insane. Because an eighth of mushrooms is three and a half doses. But you have to say like, "Wait, Max, if you're saying a dose is one gram of psilocybin mushrooms, what species of mushrooms are you talking about?"

Because out of over the 30 types of psilocybin species that not only grow around the world, but are legally shipped in spores to mushroom enthusiasts and cultivators all over the planet, how do you know that the mushrooms that you're eating are cubensis or are Golden Teachers, Purple Majesty. You know what I'm saying? And so mushrooms is something that you should, like cannabis, tiptoe with in terms of an experimentation phase. So micro dosing them by taking a tiny amount just to gauge it is what you should do. Maybe explore it a little bit further. And when you know, like, "Oh, this bag of mushrooms that I just so happened to have affects me in this way."

This Sunday, I'm going to plan a large dose, which means I'm going to take five times the small amount I took originally, maybe even 10 times and still know that I'm eating less than maybe 2.5 grams mushrooms, maybe 3 grams. Just don't ever exceed, you know, 4 grams of mushrooms unless you're ready for the big boy dose, which is considered 5 grams of mushrooms. But, you know, if you're taking 2 to 3 grams of mushrooms rooms in a safe place, your setup, you've got a game plan, you know what you're going to do in an 8-hour period, yoga, meditation, journal, draw, talk with your friend, go on a walk. You really could have an explosive experience in your own living room that could really propel your consciousness and your understanding of everything. You know, like a 30-year worth of therapy and get over some stuff.

But that's using mushrooms like purposefully. And sometimes mushrooms can be fun, like just eating a small amount at a concert or going on a hike and that's fine too. But it's just it's just not okay to just like eat some amount of some kind of mushrooms and not have a game plan and not know who you're hanging out with or what you're about to do. Because you're set, you're setting, your friends, what you're doing, what you ate could do the opposite of give you a 30-year burst through time. It could send you on a on a psychedelic hell for hours on end to the point where you actually might want to commit suicide. It's so psychologically bothersome. And that's a danger point to which is why people have to be really cautious about this stuff. And why we have to like go slow with it.

Matthew: Right. Now, what is the connection between mushrooms and Santa Claus? A lot of people don't know about this, but after you kind of explain it, they might see this in some of the artwork from years past.

Max: Yeah. And I don't know if I'm the best person to...

Matthew: That's okay.

Max: ...tell the Santa Claus story. But I never grew up with the guy. I'm a Jew. No, but the Santa Claus thing is fun. So, you know, we're talking about Amanita muscaria mushrooms. And that in and of itself is different because what we're not talking about is psychedelic mushrooms but we are talking about psychedelic mushrooms. Something really interesting about these psychedelic mushrooms that grow all over my state, they also grow all over the entire world. They are legal to possess and I guess, to use although be super, super careful because they don't have psilocybin in them. So the only types of fungus that are illegal are psilocybin mushrooms. And Amanita muscaria, the flyer agaric, the mushroom that's in your emoji on your cell phone, the Mario mushroom. The famous mushroom is the mushroom that we're talking about, the red one with the white spots.

Yeah, so the thing is the reason why you have to be careful this mushroom is let's say two are growing next to each other. Mushroom number one could be as potent as zero and mushroom number two could be as potent as two million.

Matthew: Oh my goodness.

Max: And the way that you actually gauge it is by smoking them. And the reason why you smoke them is to decarboxylate them. Similar to cannabis. Although what you're decarboxylating is the ibotenic acid, which is the part that will really mess you up, hurt you. So you actually have to cook out the ibotenic acid in order to get to the psychoactive part which is the muscomil, muscomil, muscimol.
Yeah, that's how you say it, muscimol.

And in Siberia, the Siberian shamans learned a really interesting trick of decarboxylization which is feeding these mushrooms to reindeer in that the liver of the reindeer can actually process the ibotenic acid. And, I mean, it totally makes them sick, but it just doesn't kill them. And while these reindeer are flying, literally flying reindeer, the shamans can easily catch them and capture their urine. And the shamans drink the urine of the reindeer which is just loaded with the muscimol without the IBO tannic acid. And, you know, when they drink it, they can see their reindeer flying even easier. And they begin flying themselves.

But what you have to think about like that geography of the planet, when it snows it can snow up to 20 feet and it doesn't melt the whole winter. And these Mongolian humans aren't living in skyrises. They live in I would say a half a story yurt. Like a single story yurt, right? And so imagine a whole community of people snowbound in yurts. You literally can't walk out your front door. So I hope you liked your family because you're going to be trapped in the same living room with them in the dark for six months. Going to the bathroom, eating, everything. And it's not a fun time. And it's something that they have to survive through.

And so, you know, one way that this pagan culture began this celebration is by bringing nature into their homes and having a huge feast. Kind of like a Christmas tree and a big dinner. Wink, wink. Yes, like if people don't know, all of Christmas is entirely pagan. And that's my favorite thing about the soccer moms that don't let their kids read Harry Potter because it's got witchcraft in it. It's like half their culture is witchcraft. Anyways. Anyways. Okay, so some of the men in this culture, their job is to take care of people who are trapped in the snow. They're snow bound. And how they do this is by they dig themselves out on a daily basis.

And how do they take out buckets of feces in urine out of a home and how do they deliver food and medicine into the house that snowbound? Through a chimney. And how do they get through this chimney while they're basically flying above these yurts gliding on the snow on...what does Santa use? A sleight, right? Like they've got a sled and what animals do they have up there? Reindeer? So yes, literally, this red mushroom with white all over it in winter time, these shamans dressed in these enormous coats are using reindeer and sleds flying all over the place delivering gifts through chimneys. And there's your Santa Claus, kids.

Matthew: Yeah. Gosh, it's so crazy about that stuff. It's so interesting how that stuck with the culture. Now, in terms of where you think mushrooms are going over the next 10 or 20 years or less than that, maybe next five or 10 years is it going to be we're going to be boiling the frog, as you said? But is it going to be we're going to stay in this kind of decriminalization state and at least in Colorado for some period of time?

Max: Yeah, I mean, you know, like how this following the recipe, you now have a community of people who just got really excited because of the legislation. And due to this excitement, you're starting to see the ideas of businesses popping up. It's actually been in the newspaper already. People doing micro dose psilocybin coffee businesses. Businesses where they provide the centers and the therapist where you can go and do a psilocybin treatment, kind of like I was discussing with a trip center, but kind of in a more of a legal and professional setting. But in order for any of those things to take place, the legislation has to push beyond it being simply not criminal.

Because it needs to have a medicalization or a legalization element to it in order for you to possess, give, take mushrooms and not go to jail. And so as these young businesses are becoming excited about this new frontier potential as they should be and as they should be doing their homework and being really, really, really cautious. There's going to be a community of activists who is going to be responsible for pushing the legislative envelope to the place that's going to allow these young businesses to do what they do. And something that I wish cannabis businesses did is give back to the activists that spent thousands of their free hours fighting tooth and nail, risking their lives sometime to make this multibillion dollar cannabis industry exists in the first place. Because when you participate a lot in that activism role, one thing you see is the industry that you helped to create sometimes they're not very aware of the hard work that went into it. And so paying your respects is an important thing, I believe. But, yeah, I think it's going to be a process, but I think the processes began if they get asked.

Matthew: That would be a great way of doing it is having centers where people who are nervous for the first time or even there for multiple times could go in and have one of their fears assuaged in a professional environment, know what kind of mushroom they're getting and have an idea of how it's going to impact them. And that would be a great thing if that could happen. Well, Max, a few personal development questions for you, is there a book that's had a big impact on your life or your way of thinking that you'd like to share?

Max: So the interesting thing is as an extraordinarily add dyslexic, reading is difficult for me, even though I write books. And I also I just occupy myself as a workaholic to a point where I don't give myself a lot of opportunity to sit down and read books. When I do sit up, like self-help books that I listen on Audible, like when I take long drives just to kind of think about ways just to improve myself as a person. There's been a few of those. One has been "The Miracle Morning," which is super awesome. Another one is called "Unfu*k Yourself." Fantastic book. It's really good.

But like the books that helped me become me are like the book on "The Encyclopedia of Psychoactive Plants." It's like reading a dictionary. And that kind of stuff gets me excited. But I just literally like when I have the time, I'll get this big, heavy book, put it in my lap, and I just flipped through pages. And I'll recognize a plant that I've always seen in my whole life like down at the creek and like, "No way, that's psychoactive?" And I go down rabbit holes and I go online and I start learning and I start growing and I start practicing and I start researching.

And, I mean, I just literally just pick up just texts of plants. And I'd fall in love so quick with each plant and how they can do the things that they do that I must have them. I must study them. I must keep them. I must learn from them. I must try them. And I must teach other people about them. And so I don't really sit around and I'm not part of like Oprah's book club. I'm more, you know, kind of mad scientist with a big group of different books all over the place. And I pick and choose at them. And it's a little more crazy than it is organized. But beautiful things do come from it.

Matthew: And what do you think is the most interesting thing going on in your field apart from what you're doing?

Max: The most interesting thing? Well, I mean, apart from what I'm doing, I find it really interesting how people are growing and producing cannabinoids in ways where they're not using the cannabis plant whatsoever. They just pick what cannabinoid they want to grow and grow real fast. Actually, I was listening to one of your episodes about that not too long ago, Matt. Yeah. You know, I find that really interesting. But at the same time, I saw it coming years ago and it's like how all drugs are made. So it doesn't really blow my mind. It's just outside of what I'm doing in the world of cannabis that I find interesting.

But the thing that I find the most interesting that's really happening that does involve my world though is people starting to take cannabis seriously. And that means selling it more like wine and less like cannabis. And that means a lot of the stuff we were just talking about earlier. Like having the state of California actually designate a legal Appalachian for cannabis. The first time in world history that is huge. And for people who don't understand, every white grape grower in California wishes they could call their product champagne because they could sell it for five times more. But they legally can't because it's not from the Applachia of champagne France.

And so to give growers a name and an ability to sell their product for what it deserves to be sold for instead of competing with these McDonald's this coming out of the valley for 500 bucks a pound is going to allow high quality cannabis to exist and for people to experience it by treating it in a way where people care about it by giving it truth and labeling laws. And so that's important.

Matthew: What is one thought you have that most people would disagree with you on?

Max: Oh, my gosh. I wish my girlfriend was here. Let's see. One thought...I must fill this. I don't even know if I want to tell you.

Matthew: Please. Now you got to. I'm in a safe place. I'm in the proper mindset. I'm ready.

Max: Yeah? Okay. Let's just say I've got real, real serious concerns about how far along the problem of our planet's demise is. And the way that I understand it is potentially 50 years further than where everyone else seems to be right now. And it's terrifying because I'm actually experiencing it because I grow so many different types of plants outside inside in so many different ways. And I have for so long and I'm so attentive to each and every detail, every bug, every insect, what the dirt smells like everything. Even the air feels like. Everything.

And my little antennas and my radars are just going off in ways that other people don't experience and don't see and even don't even believe is real. And it's really hard to have so much like truth and knowingness in your heart about something so important. And then to be met with people who simply just shake your head at you and think you're crazy. And so, yeah, I would say the state of where the planet is and the fact that it is much, much, much, much worse than we really know and what's even being reported. And I know a lot of people do agree with that. So there's a lot of people who don't, a lot. And so I would say that that's probably a big thing that a lot of people would probably disagree with me about.

Matthew: Yeah. I noticed the drive in across the Midwest in the summer. My windshield used to be when I was young kid is covered with insects when you'd stop at the gas station or something. Like just totally like the whole grille the windshield and everything. And now it's like there's none.

Max: And the thing that's really frustrating with the people who don't agree with this is when they don't agree from their position of science, which is the fact that the planet does this naturally and always has, and the thing that jus, like, befuddles me is like, "No, duh, the planet goes between cooling and warming's." And of course we have evidence for that. I mean, it's like every single scientist says the same thing. But the idea that it's not based on humans, like the billions of us that didn't exist a few hundred years ago that do now and the millions of types of manufacturing and industry that...I mean, like it blew my mind that producing clothing actually produces more pollution than the entire airplane industry globally.

And I'm like, "Wait, what? Like making clothes is worse than that tens of thousands of airplanes just dumping fuel in the sky on a daily basis." Like people don't even have an inkling that the fact that trash is not against the law is going to kill us. If it was, there would be millions of new jobs to fell and a planet to save. And so it's just like it's insane that people choose to not understand what is so evident that humans and our industrial revolution and actually tying this into cannabis, this actually all has everything to do with cannabis. And what's really interesting is it's because the gentleman who were sitting around a room with each other, making the choice, whether the rest of the world was going to exist on a planet that was industrious from non-renewable sources or renewable sources was a choice that a group of men made in a room.

And we're talking the oil and car manufacturing, chemical manufacturing, and paper manufacturing. In the heads of all of those multibillion dollar industry strip ease in the United States since the 1920s have one common enemy, cannabis. It was the one plant that you could make anything out of. And Henry Ford was building biodegradable cars out of cannabis and running them on cannabis fuel with the diesel engine because Rudolf Diesel designed an engine to run off of renewable plants. So when men decided that they were all competition with each other greed. It was one or the other. He was either renewable plants that weren't going to pollute the earth or a limited resource and the one that they could control which was oil. Or paper from trees that took forever to grow instead of growing entire forest overnight in Kansas in your own backyard with hemp, and same with chemicals, and same with medicine, same with cigarettes and even same with alcohol.

And so that's why the cannabis prohibition exists in the first place. And, you know, if we just chose to make every piece of plastic biodegradable out of cannabis, make our cars biodegradable, run our cars on it, our paper, our oil, I mean, cannabis even can conduct electricity. There's nothing on the planet we can't do with cannabis, which is why it's been against the law. Has nothing to do with getting high. We have a fantastic pharmaceutical industry that's there for that. So I'm concerned about the planet and in ways that a lot of people disagree with. It's frustrating. And the one thing I hope that we could all just agree on is if you wanted a new way, a new industry, a new job, new opportunities, new everything, a new world, introduce cannabis and exchange for everything else we have and have fun with it. Because anything we're doing now we can do with this plant. It's the reason why it's in the Bible.

Matthew: You know, I think about this a lot, probably not as much as you but I think about it. And I feel like there's kind of like this psychological warfare of the Hatfields and the McCoys about like, "This is happening. This is not happening. And what's the solution?" And I was thinking, you know, the solution often is proposed like a tax. And most people think about taxes like this burden they've put up with. Like when I saw how Colorado incentivized electric cars like the Nissan LEAF and stuff and Tesla's, it was very successful, very successful, along with the federal tax credits. I'm like, "Why can't we just..." I mean, most businesses will not lobby against a credit. And if taxes all go to some huge bureaucracy, like a carbon tax, they might not use that in innovative ways.

So how can we just like make a starburst of the right incentives? And I think the answer would be tax credits that allow businesses keep more money by doing the right thing in a way that is so much faster and more effective than a centralized body could do. I don't know if that's good. That's probably not a complete answer. But I feel like it would get past like global warming happening, not happening, just caught like, you know, if you make yourself have a higher ecological sustainability score, you get a tax credit for this behavior, these type of behaviors.

Max: And there's a brewery in Colorado called Asher in Boulder. And all the beer is all, you know, non-GMO produce. But how they cook the beer, all of the energy that runs the entire brewery, they cultivate themselves from the sun and from the wind and even down to the internet, the Wi-Fi they provide inside their tap room is actually Wi-Fi that's solar generated energy. And so that's like...I just love the idea that if you choose to be a business to have a zero footprint, we're in a world now with so much technology that you could achieve that. I mean, it's like you don't have to be hurting our planet more. You could actually be reducing it. And I do so as much as I can and I'm going to try to start educating people in really just fun and simple ways how I try to reduce my footprint.

So maybe they can reduce those in the same way. But you know, the thing that's the most shameful about, you know, a carbon footprint talking about cannabis is like who in the hell...it seems criminal, I'll just say that, that in the state of Colorado the cannabis industry is not allowed to grow cannabis plants with the sun. And we have some of the brightest sun in the whole country. We're a mile high. And so we have to grow cannabis indoors. And when you understand how large the cannabis industry in Colorado is, we're talking like 800, 900 licensed cannabis grows, some of which have 5,000, 1,000 watt high pressure sodium bulbs in each of them, which is a street lamp apiece, 5,000 of those in a single warehouse times hundreds and hundreds and hundreds.

It is worthy of like making your stomach a little sick. Thinking about how much coal we're ripping out of the earth in throwing into the air just to grow plants under light bulbs because someone legislatively decided we shouldn't grow them outside. And to me, that seems like, you know, a handshake with a power company. Because how could something that serious, that drastic, with such an impact that's so wrong exist so prolifically? I mean, we've had legal cannabis in Colorado since 2000 from a medical perspective. And we have a really fantastic well-developed industry and we can't let a plant grow outside? Come on, man. So, yeah, yeah. All that kind of stuff.

Matthew: Well, Max, we covered a lot of ground today here. Please let listeners know how they can find Trichome Institute and your educational materials and your Instagram feed and all that good stuff?

Max: Yeah, so you know all the normal stuff, trichomeinstitute.com. We have tons of free videos. Lots of cool stuff in our shop, courses online, Instagram, @TrichomeInstitue. Same thing with all the rest of our social media. If you want to follow me and my adventures around the world personally on Instagram, I'm Max Montrose. And I would check out Spliff Busters on YouTube. Just type in Spliff Busters. If you enjoy listening to me crush cannabis facts, it's a fun show where we do a lot of facts real quick. So I think people have fun with that. And I think it covers the basics. Yeah. Thanks so much for having me on the show again, Matt. I really appreciate it.

Matthew: Thank you, Max. It's been a pleasure. If you enjoyed the show today, please consider leaving us review on iTunes, Stitcher, or whatever app you might be using to listen to the show. Every five-star review helps us to bring the best guests to you. Learn more at cannainsider.com/itunes. What are the five disruptive trends that will impact the cannabis industry in the next five years? Find out your free report at cannainsider.com/trends. Have a suggestion for an awesome guest on CannaInsider? Simply send us an email at feedback at cannainsider.com. We'd love to hear from you.

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